Novel association of HLA-haplotypes with primary sclerosing cholangitis (PSC) in a southern European population

T. M. Neri, G. M. Cavestro, P. Seghini, P. F. Zanelli, A. Zanetti, M. Savi, M. Podda, M. Zuin, M. Colombo, A. Floreani, F. Rosina, G. Bianchi Porro, M. Strazzabosco, Lajos Okolicsanyi

Research output: Contribution to journalArticle

Abstract

Aims. In patients with with primary sclerosing cholangitis we investigated the major histocompatibility complex (MHC) genes and mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Methods. In 64 PSC patients and 183 normal controls of the same population (Northern Italy), allelic polymorphisms at the DNA level were investigated in MHC region genes: HLA-DRB1, HLA-DQB1 and HLA-B, tumour necrosis factor A (TNFA), and in CFTR gene, with polymerase chain reaction-based methodologies. Results. Frequencies of DRB1*01, DQA1*0101, DQB1*0102 (14 vs. 8%, p

Original languageEnglish
Pages (from-to)571-576
Number of pages6
JournalDigestive and Liver Disease
Volume35
Issue number8
DOIs
Publication statusPublished - Aug 2003

Keywords

  • CFTR genes
  • Chronic cholestasis
  • HLA genes

ASJC Scopus subject areas

  • Gastroenterology

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    Neri, T. M., Cavestro, G. M., Seghini, P., Zanelli, P. F., Zanetti, A., Savi, M., Podda, M., Zuin, M., Colombo, M., Floreani, A., Rosina, F., Bianchi Porro, G., Strazzabosco, M., & Okolicsanyi, L. (2003). Novel association of HLA-haplotypes with primary sclerosing cholangitis (PSC) in a southern European population. Digestive and Liver Disease, 35(8), 571-576. https://doi.org/10.1016/S1590-8658(03)00274-3