Novel benzo[ b ]thiophene derivatives as new potential antidepressants with rapid onset of action

Luis Berrade, Bárbara Aisa, María J. Ramirez, Silvia Galiano, Salvatore Guccione, Lise Román Moltzau, Finn Olav Levy, Ferdinando Nicoletti, Giuseppe Battaglia, Gemma Molinaro, Ignacio Aldana, Antonio Monge, Silvia Perez-Silanes

Research output: Contribution to journalArticlepeer-review

Abstract

We report benzo[b]thiophene derivatives synthesized according to a dual strategy. 8j, 9c, and 9e with affinity values toward 5-HT 7R and 5-HTT were selected to probe their antidepressant activity in vivo using the forced swimming text (FST). The results showed significant antidepressant activity after chronic treatment. 9c was effective in reducing the immobility time in FST even after acute treatment. These findings identify these compounds as a new class of antidepressants with a rapid onset of action.

Original languageEnglish
Pages (from-to)3086-3090
Number of pages5
JournalJournal of Medicinal Chemistry
Volume54
Issue number8
DOIs
Publication statusPublished - Apr 28 2011

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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