TY - JOUR
T1 - Novel biologics for the treatment of pediatric severe asthma
AU - Licari, Amelia
AU - Castagnoli, Riccardo
AU - Tondina, Enrico
AU - Testa, Giorgia
AU - Parisi, Giuseppe Fabio
AU - Marseglia, Alessia
AU - Brambilla, Ilaria
AU - Marseglia, Gian Luigi
N1 - Publisher Copyright:
© 2019 Bentham Science Publishers.
PY - 2019
Y1 - 2019
N2 - Estimated to represent less than 5% of all asthmatic patients, children with severe asthma experience troublesome persistent symptoms, life-threatening attacks and side effects by oral corticosteroid treatment, that significantly impact on the quality of life and on economic costs. An accurate understanding of the mechanisms of the disease has been crucial for the discovery and development of biological therapies, for which children with severe asthma are candidates. The aim of this review is to discuss the use of approved biologics for severe asthma, providing updated evidence of novel targeted therapies in the pediatric age range.
AB - Estimated to represent less than 5% of all asthmatic patients, children with severe asthma experience troublesome persistent symptoms, life-threatening attacks and side effects by oral corticosteroid treatment, that significantly impact on the quality of life and on economic costs. An accurate understanding of the mechanisms of the disease has been crucial for the discovery and development of biological therapies, for which children with severe asthma are candidates. The aim of this review is to discuss the use of approved biologics for severe asthma, providing updated evidence of novel targeted therapies in the pediatric age range.
KW - Benralizumab
KW - Children
KW - Dupilumab
KW - Mepolizumab
KW - Omalizumab
KW - Reslizumab
KW - Severe asthma
UR - http://www.scopus.com/inward/record.url?scp=85078556094&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85078556094&partnerID=8YFLogxK
U2 - 10.2174/1573398X15666190521111816
DO - 10.2174/1573398X15666190521111816
M3 - Review article
AN - SCOPUS:85078556094
VL - 15
SP - 195
EP - 204
JO - Current Respiratory Medicine Reviews
JF - Current Respiratory Medicine Reviews
SN - 1573-398X
IS - 3
ER -