Novel biologics for the treatment of pediatric severe asthma

Amelia Licari; Riccardo Castagnoli; Enrico Tondina; Giorgia Testa; Giuseppe Fabio Parisi; Alessia Marseglia; Ilaria Brambilla; Gian Luigi Marseglia

doi:10.2174/1573398X15666190521111816

Novel biologics for the treatment of pediatric severe asthma

Amelia Licari, Riccardo Castagnoli, Enrico Tondina, Giorgia Testa, Giuseppe Fabio Parisi, Alessia Marseglia, Ilaria Brambilla, Gian Luigi Marseglia

Research output: Contribution to journal › Review article › peer-review

Abstract

Estimated to represent less than 5% of all asthmatic patients, children with severe asthma experience troublesome persistent symptoms, life-threatening attacks and side effects by oral corticosteroid treatment, that significantly impact on the quality of life and on economic costs. An accurate understanding of the mechanisms of the disease has been crucial for the discovery and development of biological therapies, for which children with severe asthma are candidates. The aim of this review is to discuss the use of approved biologics for severe asthma, providing updated evidence of novel targeted therapies in the pediatric age range.

Original language	English
Pages (from-to)	195-204
Number of pages	10
Journal	Current Respiratory Medicine Reviews
Volume	15
Issue number	3
DOIs	https://doi.org/10.2174/1573398X15666190521111816
Publication status	Published - 2019

Keywords

Benralizumab
Children
Dupilumab
Mepolizumab
Omalizumab
Reslizumab
Severe asthma

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

Access to Document

10.2174/1573398X15666190521111816

Cite this

Novel biologics for the treatment of pediatric severe asthma. / Licari, Amelia; Castagnoli, Riccardo; Tondina, Enrico; Testa, Giorgia; Parisi, Giuseppe Fabio; Marseglia, Alessia; Brambilla, Ilaria; Marseglia, Gian Luigi.

In: Current Respiratory Medicine Reviews, Vol. 15, No. 3, 2019, p. 195-204.

Research output: Contribution to journal › Review article › peer-review

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abstract = "Estimated to represent less than 5% of all asthmatic patients, children with severe asthma experience troublesome persistent symptoms, life-threatening attacks and side effects by oral corticosteroid treatment, that significantly impact on the quality of life and on economic costs. An accurate understanding of the mechanisms of the disease has been crucial for the discovery and development of biological therapies, for which children with severe asthma are candidates. The aim of this review is to discuss the use of approved biologics for severe asthma, providing updated evidence of novel targeted therapies in the pediatric age range.",

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AU - Marseglia, Alessia

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KW - Dupilumab

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KW - Omalizumab

KW - Reslizumab

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Novel biologics for the treatment of pediatric severe asthma

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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