Novel biotinylated bile acid amphiphiles: Micellar aggregates formation and interaction with hepatocytes

Luca Rizzi; Marta Braschi; Miriam Colombo; Nadia Vaiana; Gianpaolo Tibolla; Giuseppe Danilo Norata; Alberico Luigi Catapano; Sergio Romeo; Davide Prosperi

doi:10.1039/c0ob00878h

Novel biotinylated bile acid amphiphiles: Micellar aggregates formation and interaction with hepatocytes

Luca Rizzi, Marta Braschi, Miriam Colombo, Nadia Vaiana, Gianpaolo Tibolla, Giuseppe Danilo Norata, Alberico Luigi Catapano, Sergio Romeo, Davide Prosperi

IRCCS Multimedica

Research output: Contribution to journal › Article › peer-review

Abstract

Amphiphilic bile acids linked through an oligoethylene glycol to a biotin moiety were synthesized and shown to create micellar structures in aqueous environment, interact with avidin and be efficiently incorporated into hepatocyte cells, suggesting their potential as a drug delivery system against liver diseases.

Original language	English
Pages (from-to)	2899-2905
Number of pages	7
Journal	Organic and Biomolecular Chemistry
Volume	9
Issue number	8
DOIs	https://doi.org/10.1039/c0ob00878h
Publication status	Published - Apr 21 2011

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Organic Chemistry
Biochemistry

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10.1039/c0ob00878h

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Novel biotinylated bile acid amphiphiles : Micellar aggregates formation and interaction with hepatocytes. / Rizzi, Luca; Braschi, Marta; Colombo, Miriam; Vaiana, Nadia; Tibolla, Gianpaolo; Norata, Giuseppe Danilo; Catapano, Alberico Luigi; Romeo, Sergio; Prosperi, Davide.

In: Organic and Biomolecular Chemistry, Vol. 9, No. 8, 21.04.2011, p. 2899-2905.

Research output: Contribution to journal › Article › peer-review

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