Novel biotinylated bile acid amphiphiles: Micellar aggregates formation and interaction with hepatocytes

Luca Rizzi, Marta Braschi, Miriam Colombo, Nadia Vaiana, Gianpaolo Tibolla, Giuseppe Danilo Norata, Alberico Luigi Catapano, Sergio Romeo, Davide Prosperi

Research output: Contribution to journalArticlepeer-review

Abstract

Amphiphilic bile acids linked through an oligoethylene glycol to a biotin moiety were synthesized and shown to create micellar structures in aqueous environment, interact with avidin and be efficiently incorporated into hepatocyte cells, suggesting their potential as a drug delivery system against liver diseases.

Original languageEnglish
Pages (from-to)2899-2905
Number of pages7
JournalOrganic and Biomolecular Chemistry
Volume9
Issue number8
DOIs
Publication statusPublished - Apr 21 2011

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Biochemistry

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