Novel double resonance pulse sequence for low sensitivity nuclei selection

S. Capuani, L. Mancini, B. Maraviglia, M. Sette, M. Paci

Research output: Contribution to journalArticlepeer-review


A new double resonance sequence, capable of selecting specific protons coupled to low sensitivity nuclei, while very efficiently suppressing the water and the uncoupled protons signal, is here proposed. Water suppression is found to be more than five orders of magnitude without using either advanced phase cycling or gradient pulses or presaturation pulse sequences. This method exploits heteronuclear J-coupling and chemical shift interactions to select the required resonances. The reported results, obtained in rat cells, show the real efficiency of the method proposed, that appears to be a relevant tool for in vivo spectroscopic and metabolic studies.

Original languageEnglish
Pages (from-to)222-228
Number of pages7
JournalChemical Physics Letters
Issue number3-4
Publication statusPublished - Jan 14 2000

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Spectroscopy
  • Atomic and Molecular Physics, and Optics


Dive into the research topics of 'Novel double resonance pulse sequence for low sensitivity nuclei selection'. Together they form a unique fingerprint.

Cite this