Novel ether-linkages containing aliphatic copolyesters of poly(butylene 1,4-cyclohexanedicarboxylate) as promising candidates for biomedical applications

Matteo Gigli, Nadia Lotti, Marco Vercellino, Livia Visai, Andrea Munari

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

A new class of biodegradable and biocompatible poly(butylene 1,4-cyclohexanedicarboxylate) based random copolymers are proposed for biomedical applications. The introduction of ether-oxygen containing BDG sequences along the PBCE macromolecular chain is expected to remarkably improve chain flexibility and surface hydrophilicity due to the presence of highly electronegative oxygen atoms. P(BCExBDGy) copolymers were synthesized by polycondensation. The homopolymer PBCE and three copolymers, namely (P(BCE70BDG30), P(BCE55BDG45) and P(BCE40BDG60)) were characterized from the molecular, thermal, structural and mechanical point of view. Hydrolytic degradation studies in the presence and absence of hog-pancreas lipase were performed under physiological conditions. To evaluate the diffusion profile of small molecules through the polymer matrix, the release behaviour of fluorescein isothiocyanate (FITC) was investigated. For biocompatibility studies, cell adhesion and proliferation of murine fibroblast (L929) and endocrine pancreatic (INS-1) cells were performed on each polymeric film. Results showed that solid-state properties can be tailored by simply varying copolymers' composition. Crystallinity degree and hydrophobicity significantly decreased with the increase of BDG co-unit mol%. Moreover, mechanical properties and biodegradability of PBCE, both depending on crystallinity degree, were remarkably improved: P(BCE40BDG60) showed an elastomeric behaviour with εb over 600% and, as regard to biodegradability, after 98 days it lost over 60% of its initial weight if incubated in the presence of the pancreatic lipase. Lastly, the newly developed biomaterials resulted not cytotoxic with both types of cells and could be properly tailored for biomedical applications varying the content of BDG co-unit mol%.

Original languageEnglish
Pages (from-to)86-97
Number of pages12
JournalMaterials Science and Engineering C
Volume34
Issue number1
DOIs
Publication statusPublished - 2014

Fingerprint

butenes
Lipase
Hydrophobic and Hydrophilic Interactions
linkages
Ether
Ethers
ethers
copolymers
Copolymers
Oxygen
biodegradability
Biodegradability
Lipases
Biocompatible Materials
Fluorescein
Cell Adhesion
Pancreas
crystallinity
Polymers
Fibroblasts

Keywords

  • 4-cyclohexanedicarboxylate)
  • Biocompatibility
  • Biodegradation
  • Ether linkages
  • murine fibroblast cells
  • pancreatic cells
  • Poly(butylene 1
  • Random copolymers
  • Solid-state properties

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering
  • Mechanics of Materials
  • Medicine(all)

Cite this

Novel ether-linkages containing aliphatic copolyesters of poly(butylene 1,4-cyclohexanedicarboxylate) as promising candidates for biomedical applications. / Gigli, Matteo; Lotti, Nadia; Vercellino, Marco; Visai, Livia; Munari, Andrea.

In: Materials Science and Engineering C, Vol. 34, No. 1, 2014, p. 86-97.

Research output: Contribution to journalArticle

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