Novel HBsAg markers tightly correlate with occult HBV infection and strongly affect HBsAg detection

Valentina Svicher, Valeria Cento, Martina Bernassola, Maria Neumann-Fraune, Formijn Van Hemert, Mengjie Chen, Romina Salpini, Chang Liu, Roberta Longo, Michela Visca, Sara Romano, Valeria Micheli, Ada Bertoli, Caterina Gori, Francesca Ceccherini-Silberstein, Cesare Sarrecchia, Massimo Andreoni, Mario Angelico, Antonella Ursitti, Alberto SpanòJing Maria Zhang, Jens Verheyen, Giuseppina Cappiello, Carlo Federico Perno

Research output: Contribution to journalArticle

Abstract

Occult HBV infection (OBI) is a threat for the safety of blood-supply, and has been associated with the onset of HBV-related hepatocellular carcinoma and lymphomagenesis. Nevertheless, genetic markers in HBsAg (particularly in D-genotype, the most common in Europe) significantly associated with OBI in vivo are missing. Thus, the goal of this study is to define: (i) prevalence and clinical profile of OBI among blood-donors; (ii) HBsAg-mutations associated with OBI; (iii) their impact on HBsAg-detection. OBI was searched among 422,278 blood-donors screened by Nucleic-Acid-Testing. Following Taormina-OBI-definition, 26 (0.006%) OBI-patients were identified. Despite viremia

Original languageEnglish
Pages (from-to)86-93
Number of pages8
JournalAntiviral Research
Volume93
Issue number1
DOIs
Publication statusPublished - Jan 2012

Keywords

  • HBsAg detection
  • HBsAg structure
  • HBV
  • Occult infection

ASJC Scopus subject areas

  • Virology
  • Pharmacology

Fingerprint Dive into the research topics of 'Novel HBsAg markers tightly correlate with occult HBV infection and strongly affect HBsAg detection'. Together they form a unique fingerprint.

  • Cite this

    Svicher, V., Cento, V., Bernassola, M., Neumann-Fraune, M., Hemert, F. V., Chen, M., Salpini, R., Liu, C., Longo, R., Visca, M., Romano, S., Micheli, V., Bertoli, A., Gori, C., Ceccherini-Silberstein, F., Sarrecchia, C., Andreoni, M., Angelico, M., Ursitti, A., ... Perno, C. F. (2012). Novel HBsAg markers tightly correlate with occult HBV infection and strongly affect HBsAg detection. Antiviral Research, 93(1), 86-93. https://doi.org/10.1016/j.antiviral.2011.10.022