Novel insights in dopamine receptor physiology

Rosario Pivonello, Diego Ferone, Gaetano Lombardi, Annamaria Colao, Steven W J Lamberts, Leo J. Hofland

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

The dopaminergic system has a pivotal role in the central nervous system but also plays important roles in the periphery, mainly in the endocrine system. Dopamine exerts its functions via five different receptors, named D 1-D5, belonging to the category of G protein coupled membrane receptors. Dopamine receptors are heterogeneously expressed in different cells, tissues and organs, where they stimulate or inhibit different functions, including neurotransmission and hormone synthesis and secretion. In particular, the dopamineric system has a pivotal role in the physiological regulation of the hypothalamus-pituitary-adrenal axis. Recent data have demonstrated the expression and function of dopamine receptors not only in endocrine organs but also in endocrine tumors, mainly those belonging to the hypothalamus-pituitary-adrenal axis, and also in the so-called 'neuroendocrine' tumors. These data confirm the important role of the dopaminergic system in this endocrine axis, as well as in the neuroendocrine system. This review summarizes the main structural and functional characteristics of dopamine receptors, emphasizing the most recent novelties, and focused on the physiological and pathological regulation of the hypothalamus-pituitary-adrenal axis by the dopaminergic system. In addition, the recent findings on the relationship between dopamine receptors and neuroendocrine tumors are summarized.

Original languageEnglish
JournalEuropean Journal of Endocrinology, Supplement
Volume156
Issue number1
DOIs
Publication statusPublished - Apr 2007

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Dopamine Receptors
Hypothalamus
Endocrine System
Neuroendocrine Tumors
Neurosecretory Systems
G-Protein-Coupled Receptors
Synaptic Transmission
Dopamine
Central Nervous System
Hormones
Membranes
Neoplasms

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Pivonello, R., Ferone, D., Lombardi, G., Colao, A., Lamberts, S. W. J., & Hofland, L. J. (2007). Novel insights in dopamine receptor physiology. European Journal of Endocrinology, Supplement, 156(1). https://doi.org/10.1530/eje.1.02353

Novel insights in dopamine receptor physiology. / Pivonello, Rosario; Ferone, Diego; Lombardi, Gaetano; Colao, Annamaria; Lamberts, Steven W J; Hofland, Leo J.

In: European Journal of Endocrinology, Supplement, Vol. 156, No. 1, 04.2007.

Research output: Contribution to journalArticle

Pivonello, R, Ferone, D, Lombardi, G, Colao, A, Lamberts, SWJ & Hofland, LJ 2007, 'Novel insights in dopamine receptor physiology', European Journal of Endocrinology, Supplement, vol. 156, no. 1. https://doi.org/10.1530/eje.1.02353
Pivonello, Rosario ; Ferone, Diego ; Lombardi, Gaetano ; Colao, Annamaria ; Lamberts, Steven W J ; Hofland, Leo J. / Novel insights in dopamine receptor physiology. In: European Journal of Endocrinology, Supplement. 2007 ; Vol. 156, No. 1.
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