Novel insights into breast cancer progression and metastasis: A multidisciplinary opportunity to transition from biology to clinical oncology

Manuel Scimeca, Nicoletta Urbano, Rita Bonfiglio, Andrea Duggento, Nicola Toschi, Orazio Schillaci, Elena Bonanno

Research output: Contribution to journalReview article

Abstract

According to the most recent epidemiological studies, breast cancer shows the highest incidence and the second leading cause of death in women. Cancer progression and metastasis are the main events related to poor survival of breast cancer patients. This can be explained by the presence of highly resistant to chemo- and radiotherapy stem cells in many breast tumor tissues. In this context, numerous studies highlighted the possible involvement of epithelial to mesenchymal transition phenomenon as biological program to generate cancer stem cells, and thus participate to both metastatic and drug resistance process. Therefore, the comprehension of mechanisms (both cellular and molecular) involved in breast cancer occurrence and progression can lay the foundation for the development of new diagnostic and therapeutical protocols. In this review, we reported the most important findings in the field of breast cancer highlighting the most recent data concerning breast tumor biology, diagnosis and therapy.

Original languageEnglish
Pages (from-to)138-148
Number of pages11
JournalBiochimica et Biophysica Acta - Reviews on Cancer
Volume1872
Issue number1
DOIs
Publication statusPublished - Aug 2019

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Keywords

  • Biomarkers, Tumor/genetics
  • Breast Neoplasms/drug therapy
  • Disease Progression
  • Drug Resistance, Neoplasm/genetics
  • Epithelial-Mesenchymal Transition/genetics
  • Female
  • Humans
  • Medical Oncology/trends
  • Neoplasm Metastasis

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