Novel Insights into the Mechanisms Regulating Pro-Atrial Natriuretic Peptide Cleavage in the Heart and Blood Pressure Regulation: Proprotein Convertase Subtilisin/Kexin 6 Is the Corin Activating Enzyme

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The biologically active carboxyterminal peptide (αANP), a cardiac hormone that regulates blood pressure through natriuretic, diuretic, and vasorelaxant properties, is released from cleavage of a precursor pro-atrial natriuretic peptide (pro-ANP) form by corin. A recently published study in Nature Medicine identified proprotein convertase subtilisin/kexin 6 (PCSK6), a component of the PCSK protease family, as the natural corin activating enzyme. This key processing step of pro-ANP seems to contribute to blood pressure homeostasis and hence to hypertension development.

Original languageEnglish
Pages (from-to)196-198
Number of pages3
JournalCirculation Research
Volume118
Issue number2
DOIs
Publication statusPublished - Jan 22 2016

Fingerprint

Proprotein Convertases
Subtilisin
Atrial Natriuretic Factor
Blood Pressure
Enzymes
Vasodilator Agents
Diuretics
Homeostasis
Peptide Hydrolases
Medicine
Hormones
Hypertension
Peptides

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

@article{b840b248711d4005992ac164ab378861,
title = "Novel Insights into the Mechanisms Regulating Pro-Atrial Natriuretic Peptide Cleavage in the Heart and Blood Pressure Regulation: Proprotein Convertase Subtilisin/Kexin 6 Is the Corin Activating Enzyme",
abstract = "The biologically active carboxyterminal peptide (αANP), a cardiac hormone that regulates blood pressure through natriuretic, diuretic, and vasorelaxant properties, is released from cleavage of a precursor pro-atrial natriuretic peptide (pro-ANP) form by corin. A recently published study in Nature Medicine identified proprotein convertase subtilisin/kexin 6 (PCSK6), a component of the PCSK protease family, as the natural corin activating enzyme. This key processing step of pro-ANP seems to contribute to blood pressure homeostasis and hence to hypertension development.",
author = "Massimo Volpe and Speranza Rubattu",
year = "2016",
month = "1",
day = "22",
doi = "10.1161/CIRCRESAHA.115.307875",
language = "English",
volume = "118",
pages = "196--198",
journal = "Circulation Research",
issn = "0009-7330",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Novel Insights into the Mechanisms Regulating Pro-Atrial Natriuretic Peptide Cleavage in the Heart and Blood Pressure Regulation

T2 - Proprotein Convertase Subtilisin/Kexin 6 Is the Corin Activating Enzyme

AU - Volpe, Massimo

AU - Rubattu, Speranza

PY - 2016/1/22

Y1 - 2016/1/22

N2 - The biologically active carboxyterminal peptide (αANP), a cardiac hormone that regulates blood pressure through natriuretic, diuretic, and vasorelaxant properties, is released from cleavage of a precursor pro-atrial natriuretic peptide (pro-ANP) form by corin. A recently published study in Nature Medicine identified proprotein convertase subtilisin/kexin 6 (PCSK6), a component of the PCSK protease family, as the natural corin activating enzyme. This key processing step of pro-ANP seems to contribute to blood pressure homeostasis and hence to hypertension development.

AB - The biologically active carboxyterminal peptide (αANP), a cardiac hormone that regulates blood pressure through natriuretic, diuretic, and vasorelaxant properties, is released from cleavage of a precursor pro-atrial natriuretic peptide (pro-ANP) form by corin. A recently published study in Nature Medicine identified proprotein convertase subtilisin/kexin 6 (PCSK6), a component of the PCSK protease family, as the natural corin activating enzyme. This key processing step of pro-ANP seems to contribute to blood pressure homeostasis and hence to hypertension development.

UR - http://www.scopus.com/inward/record.url?scp=84955305295&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84955305295&partnerID=8YFLogxK

U2 - 10.1161/CIRCRESAHA.115.307875

DO - 10.1161/CIRCRESAHA.115.307875

M3 - Article

C2 - 26838312

AN - SCOPUS:84955305295

VL - 118

SP - 196

EP - 198

JO - Circulation Research

JF - Circulation Research

SN - 0009-7330

IS - 2

ER -