Novel Instruments for the Implementation of Electrochemotherapy Protocols: From Bench Side to Veterinary Clinic

Enrico P Spugnini; Stefano Fais; Tommaso Azzarito; Alfonso Baldi

doi:10.1002/jcp.25505

Novel Instruments for the Implementation of Electrochemotherapy Protocols: From Bench Side to Veterinary Clinic

Enrico P Spugnini, Stefano Fais, Tommaso Azzarito, Alfonso Baldi

Istituto Superiore di Sanita'

Research output: Contribution to journal › Review article › peer-review

Abstract

Electrochemotherapy (ECT) is a medical strategy that allows an increased efficacy of chemotherapy agents after the application of permeabilizing electric pulses having appropriate characteristics (form, voltage, frequency). In the past 10 years, the clinical efficacy of this therapeutic approach in several spontaneous models of tumors in animals has been shown. Moreover, some of the molecular and cellular mechanisms responsible for this phenomenon have been elucidated. Our group has been deeply involved in the development of new ECT protocols for companion animals, implementing the use of the technique as first line treatment, and evaluating different chemotherapy agents in laboratory animals as well as pets. This article summarizes the most important advances in veterinary ECT, including the development of novel equipment, therapeutic protocols, and their translation to humans. J. Cell. Physiol. 232: 490-495, 2017. © 2016 Wiley Periodicals, Inc.

Original language	English
Pages (from-to)	490-495
Number of pages	6
Journal	Journal of Cellular Physiology
Volume	232
Issue number	3
DOIs	https://doi.org/10.1002/jcp.25505
Publication status	Published - Mar 2017

Keywords

Animals
Electricity
Electrochemotherapy/methods
Electroporation
Hospitals, Animal
Humans
Translational Medical Research

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title = "Novel Instruments for the Implementation of Electrochemotherapy Protocols: From Bench Side to Veterinary Clinic",

abstract = "Electrochemotherapy (ECT) is a medical strategy that allows an increased efficacy of chemotherapy agents after the application of permeabilizing electric pulses having appropriate characteristics (form, voltage, frequency). In the past 10 years, the clinical efficacy of this therapeutic approach in several spontaneous models of tumors in animals has been shown. Moreover, some of the molecular and cellular mechanisms responsible for this phenomenon have been elucidated. Our group has been deeply involved in the development of new ECT protocols for companion animals, implementing the use of the technique as first line treatment, and evaluating different chemotherapy agents in laboratory animals as well as pets. This article summarizes the most important advances in veterinary ECT, including the development of novel equipment, therapeutic protocols, and their translation to humans. J. Cell. Physiol. 232: 490-495, 2017. {\textcopyright} 2016 Wiley Periodicals, Inc.",

keywords = "Animals, Electricity, Electrochemotherapy/methods, Electroporation, Hospitals, Animal, Humans, Translational Medical Research",

author = "Spugnini, {Enrico P} and Stefano Fais and Tommaso Azzarito and Alfonso Baldi",

note = "{\textcopyright} 2016 Wiley Periodicals, Inc.",

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T1 - Novel Instruments for the Implementation of Electrochemotherapy Protocols

T2 - From Bench Side to Veterinary Clinic

AU - Spugnini, Enrico P

AU - Fais, Stefano

AU - Azzarito, Tommaso

AU - Baldi, Alfonso

PY - 2017/3

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N2 - Electrochemotherapy (ECT) is a medical strategy that allows an increased efficacy of chemotherapy agents after the application of permeabilizing electric pulses having appropriate characteristics (form, voltage, frequency). In the past 10 years, the clinical efficacy of this therapeutic approach in several spontaneous models of tumors in animals has been shown. Moreover, some of the molecular and cellular mechanisms responsible for this phenomenon have been elucidated. Our group has been deeply involved in the development of new ECT protocols for companion animals, implementing the use of the technique as first line treatment, and evaluating different chemotherapy agents in laboratory animals as well as pets. This article summarizes the most important advances in veterinary ECT, including the development of novel equipment, therapeutic protocols, and their translation to humans. J. Cell. Physiol. 232: 490-495, 2017. © 2016 Wiley Periodicals, Inc.

AB - Electrochemotherapy (ECT) is a medical strategy that allows an increased efficacy of chemotherapy agents after the application of permeabilizing electric pulses having appropriate characteristics (form, voltage, frequency). In the past 10 years, the clinical efficacy of this therapeutic approach in several spontaneous models of tumors in animals has been shown. Moreover, some of the molecular and cellular mechanisms responsible for this phenomenon have been elucidated. Our group has been deeply involved in the development of new ECT protocols for companion animals, implementing the use of the technique as first line treatment, and evaluating different chemotherapy agents in laboratory animals as well as pets. This article summarizes the most important advances in veterinary ECT, including the development of novel equipment, therapeutic protocols, and their translation to humans. J. Cell. Physiol. 232: 490-495, 2017. © 2016 Wiley Periodicals, Inc.

KW - Animals

KW - Electricity

KW - Electrochemotherapy/methods

KW - Electroporation

KW - Hospitals, Animal

KW - Humans

KW - Translational Medical Research

U2 - 10.1002/jcp.25505

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