Novel MIPs-parabens based SPE stationary phases characterization and application

Angela Tartaglia, Abuzar Kabir, Songul Ulusoy, Halil Ibrahim Ulusoy, Giuseppe Maria Merone, Fabio Savini, Cristian D’Ovidio, Ugo de Grazia, Serena Gabrielli, Fabio Maroni, Pantaleone Bruni, Fausto Croce, Dora Melucci, Kenneth G. Furton, Marcello Locatelli

Research output: Contribution to journalArticlepeer-review


In this work, the synthesis, characterization, and application of novel parabens imprinted polymers as highly selective solid-phase extraction (SPE) sorbents have been reported. The imprinted polymers were created using sol–gel molecular imprinting process. All the seven parabens were considered herein in order to check the phase selectivity. By means of a validated HPLC-photodiode array detector (PDA) method all seven parabens were resolved in a single chromatographic run of 25 min. These SPE sorbents, in-house packed in SPE empty cartridges, were first characterized in terms of extraction capability, breakthrough volume, retention volume, hold-up volume, number of theoretical plates, and retention factor. Finally, the device was applied to a real urine sample to check the method feasibility on a very complex matrix. The new paraben imprinted SPE sorbents, not yet present in the literature, potentially encourage the development of novel molecularly imprinted polymers (MIPs) to enhance the extraction efficiency, and consequently the overall analytical performances, when the trace quantification is required.

Original languageEnglish
Article number3334
Issue number18
Publication statusPublished - Sep 13 2019


  • Biological matrix
  • Extraction procedure
  • MIPs
  • Parabens
  • Stationary phase characterization

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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