Novel nano-composite multi-layered biomaterial for the treatment of multifocal degenerative cartilage lesions

Elizaveta Kon, M. Delcogliano, G. Filardo, G. Altadonna, M. Marcacci

Research output: Contribution to journalArticle

Abstract

We report on a 46-year-old athletic patient, previously treated with anterior cruciate ligament reconstruction, with large degenerative chondral lesions of the medial femoral condyle, trochlea and patella, which was successfully treated with a closing-wedge high tibial osteotomy and the implant of a newly developed biomimetic nanostructured osteochondral bioactive scaffold. After 1 year of follow-up the patient was pain-free, had full knee range of motion, and had returned to his pre-operation level of athletic activity. MRI evaluation at 6 months showed that the implant gave a hyaline-like signal as well as a good restoration of the articular surface, with minimal subchondral bone oedema. Subchondral oedema was almost non-visible at 12 months.

Original languageEnglish
Pages (from-to)1312-1315
Number of pages4
JournalKnee Surgery, Sports Traumatology, Arthroscopy
Volume17
Issue number11
DOIs
Publication statusPublished - Oct 2009

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Keywords

  • Biomimetic scaffold
  • Cartilage regeneration
  • Degenerative lesions
  • Osteochondral defect

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Surgery

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