Novel nonpharmacologic perspectives for the treatment of task-specific focal hand dystonia

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Narrative Review: The pathophysiology of focal hand dystonia (FHD) has not yet been completely clarified. Although there is a loss of inhibition at multiple levels of the central nervous system, maladaptive plasticity of the cerebral cortex as well as impairments in sensory and motor representations have also been reported. All of these abnormalities can be viewed as an epiphenomenon of the primary-still unknown-abnormality underlying focal dystonia. The purpose of this review is to describe the underlying constructs of novel nonpharmacologic approaches for the treatment of FHD. Alternative or complementary approaches to botulinum toxin injections such as behavioral training strategies and brain stimulation techniques are reviewed. None of the proposed treatments appears to be definitive and applicable to all patients with FHD. Each treatment strategy elicited some benefit in a fraction of patients. The combination of more than one approach (retraining, immobilization, botulinum toxin, neuromodulation, etc.) could lead to a better control of FHD.

Original languageEnglish
Pages (from-to)156-162
Number of pages7
JournalJournal of Hand Therapy
Volume22
Issue number2
DOIs
Publication statusPublished - Apr 2009

Fingerprint

Botulinum Toxins
Dystonic Disorders
Therapeutics
Immobilization
Cerebral Cortex
Central Nervous System
Injections
Focal Task-Specific Dystonia
Brain

ASJC Scopus subject areas

  • Rehabilitation
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Novel nonpharmacologic perspectives for the treatment of task-specific focal hand dystonia. / Cogiamanian, Filippo; Barbieri, Sergio; Priori, Alberto.

In: Journal of Hand Therapy, Vol. 22, No. 2, 04.2009, p. 156-162.

Research output: Contribution to journalArticle

@article{0db7d9b63899456e8f678f91a946f346,
title = "Novel nonpharmacologic perspectives for the treatment of task-specific focal hand dystonia",
abstract = "Narrative Review: The pathophysiology of focal hand dystonia (FHD) has not yet been completely clarified. Although there is a loss of inhibition at multiple levels of the central nervous system, maladaptive plasticity of the cerebral cortex as well as impairments in sensory and motor representations have also been reported. All of these abnormalities can be viewed as an epiphenomenon of the primary-still unknown-abnormality underlying focal dystonia. The purpose of this review is to describe the underlying constructs of novel nonpharmacologic approaches for the treatment of FHD. Alternative or complementary approaches to botulinum toxin injections such as behavioral training strategies and brain stimulation techniques are reviewed. None of the proposed treatments appears to be definitive and applicable to all patients with FHD. Each treatment strategy elicited some benefit in a fraction of patients. The combination of more than one approach (retraining, immobilization, botulinum toxin, neuromodulation, etc.) could lead to a better control of FHD.",
author = "Filippo Cogiamanian and Sergio Barbieri and Alberto Priori",
year = "2009",
month = "4",
doi = "10.1016/j.jht.2008.11.008",
language = "English",
volume = "22",
pages = "156--162",
journal = "Journal of Hand Therapy",
issn = "0894-1130",
publisher = "Hanley and Belfus Inc.",
number = "2",

}

TY - JOUR

T1 - Novel nonpharmacologic perspectives for the treatment of task-specific focal hand dystonia

AU - Cogiamanian, Filippo

AU - Barbieri, Sergio

AU - Priori, Alberto

PY - 2009/4

Y1 - 2009/4

N2 - Narrative Review: The pathophysiology of focal hand dystonia (FHD) has not yet been completely clarified. Although there is a loss of inhibition at multiple levels of the central nervous system, maladaptive plasticity of the cerebral cortex as well as impairments in sensory and motor representations have also been reported. All of these abnormalities can be viewed as an epiphenomenon of the primary-still unknown-abnormality underlying focal dystonia. The purpose of this review is to describe the underlying constructs of novel nonpharmacologic approaches for the treatment of FHD. Alternative or complementary approaches to botulinum toxin injections such as behavioral training strategies and brain stimulation techniques are reviewed. None of the proposed treatments appears to be definitive and applicable to all patients with FHD. Each treatment strategy elicited some benefit in a fraction of patients. The combination of more than one approach (retraining, immobilization, botulinum toxin, neuromodulation, etc.) could lead to a better control of FHD.

AB - Narrative Review: The pathophysiology of focal hand dystonia (FHD) has not yet been completely clarified. Although there is a loss of inhibition at multiple levels of the central nervous system, maladaptive plasticity of the cerebral cortex as well as impairments in sensory and motor representations have also been reported. All of these abnormalities can be viewed as an epiphenomenon of the primary-still unknown-abnormality underlying focal dystonia. The purpose of this review is to describe the underlying constructs of novel nonpharmacologic approaches for the treatment of FHD. Alternative or complementary approaches to botulinum toxin injections such as behavioral training strategies and brain stimulation techniques are reviewed. None of the proposed treatments appears to be definitive and applicable to all patients with FHD. Each treatment strategy elicited some benefit in a fraction of patients. The combination of more than one approach (retraining, immobilization, botulinum toxin, neuromodulation, etc.) could lead to a better control of FHD.

UR - http://www.scopus.com/inward/record.url?scp=64849108153&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=64849108153&partnerID=8YFLogxK

U2 - 10.1016/j.jht.2008.11.008

DO - 10.1016/j.jht.2008.11.008

M3 - Article

VL - 22

SP - 156

EP - 162

JO - Journal of Hand Therapy

JF - Journal of Hand Therapy

SN - 0894-1130

IS - 2

ER -