Inflammatory cytokines act in cascades. Pro and anti-inflammatory signals regulate the production of primary and secondary inflammatory cytokines. A number of studies have investigated the actual role played by the two receptors, RI and RII, in interleukin (IL)-1 signaling. All available evidences, including tissue distribution and monoclonal antibodies blocking studies, indicate that IL-1-induced activities are mediated exclusively via the IL-1RI, whereas IL-1RII has no signaling activity and inhibits IL-1 effects by acting as a decoy for IL-1, thus sequestering it and preventing the cytokine from binding to the IL-1RI, IL-1RII may represent a physiological pathway of inhibition of IL-1. Induction of expression and release of the IL-1RII may contribute to the antiinflammatory properties of Th2-derived cytokines and glucocorticoids. Other studies on chemokine receptors show that lipopolysaccharides cause a drastic and rapid downregulation of the expression of CCR2, a receptor for macrophage chemotactic proteins (MCP)-1 and -3.
|Number of pages||4|
|Publication status||Published - 1998|
ASJC Scopus subject areas
- Applied Microbiology and Biotechnology