Novel pathways for negative regulation of inflammatory cytokines

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Inflammatory cytokines act in cascades. Pro and anti-inflammatory signals regulate the production of primary and secondary inflammatory cytokines. A number of studies have investigated the actual role played by the two receptors, RI and RII, in interleukin (IL)-1 signaling. All available evidences, including tissue distribution and monoclonal antibodies blocking studies, indicate that IL-1-induced activities are mediated exclusively via the IL-1RI, whereas IL-1RII has no signaling activity and inhibits IL-1 effects by acting as a decoy for IL-1, thus sequestering it and preventing the cytokine from binding to the IL-1RI, IL-1RII may represent a physiological pathway of inhibition of IL-1. Induction of expression and release of the IL-1RII may contribute to the antiinflammatory properties of Th2-derived cytokines and glucocorticoids. Other studies on chemokine receptors show that lipopolysaccharides cause a drastic and rapid downregulation of the expression of CCR2, a receptor for macrophage chemotactic proteins (MCP)-1 and -3.

Original languageEnglish
Pages (from-to)137-140
Number of pages4
JournalBiotecnologia Aplicada
Issue number3
Publication statusPublished - 1998


  • Chemokines
  • Inflammation
  • Interleukin-1
  • Receptors

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology


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