Novel Perspectives in Redox Biology and Pathophysiology of Failing Myocytes: Modulation of the Intramyocardial Redox Milieu for Therapeutic Interventions -A Review Article from the Working Group of Cardiac Cell Biology, Italian Society of Cardiology

Alessia Arcaro, Flora Pirozzi, Annalisa Angelini, Cristina Chimenti, Lia Crotti, Carla Giordano, Daniele Mancardi, Daniele Torella, Carlo G. Tocchetti

Research output: Contribution to journalArticle

Abstract

The prevalence of heart failure (HF) is still increasing worldwide, with enormous human, social, and economic costs, in spite of huge efforts in understanding pathogenetic mechanisms and in developing effective therapies that have transformed this syndrome into a chronic disease. Myocardial redox imbalance is a hallmark of this syndrome, since excessive reactive oxygen and nitrogen species can behave as signaling molecules in the pathogenesis of hypertrophy and heart failure, leading to dysregulation of cellular calcium handling, of the contractile machinery, of myocardial energetics and metabolism, and of extracellular matrix deposition. Recently, following new interesting advances in understanding myocardial ROS and RNS signaling pathways, new promising therapeutical approaches with antioxidant properties are being developed, keeping in mind that scavenging ROS and RNS tout court is detrimental as well, since these molecules also play a role in physiological myocardial homeostasis.

Original languageEnglish
Article number6353469
JournalOxidative Medicine and Cellular Longevity
Volume2016
DOIs
Publication statusPublished - 2016

ASJC Scopus subject areas

  • Cell Biology
  • Ageing
  • Biochemistry

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