Abstract
The foetal-maternal interaction results in the induction of a local inflammatory response and a state of systemic inflammation. Several factors are involved in successful embryonic implantation, including hormones, growth factors, cytokines, chemokines, adhesion molecules, extracellular matrix components, and matrix-degrading enzymes. The enriched cytokine milieu associated to implantation is likely to control trophoblast migration and differentiation, leukocyte influx and activation, complement activation, as well as angiogenic and angiostatic processes in the implantation site. Finally, these mediators play a key role in tuning the immune responses to protect the foetus from infections as well as from maternal rejection. Here, the role of two new players involved in regulating inflammation at the maternal-foetal interface will be discussed: the long pentraxin PTX3 and the decoy receptor for inflammatory chemokines D6.
| Original language | English |
|---|---|
| Pages (from-to) | 41-50 |
| Number of pages | 10 |
| Journal | Advances in Neuroimmune Biology |
| Volume | 2 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - 2011 |
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Keywords
- chemokines
- decoy receptor
- female fertility
- inflammation
- Pentraxins
ASJC Scopus subject areas
- Immunology
- Endocrine and Autonomic Systems
- Endocrinology
Cite this
Novel players in female fertility : The long pentraxin PTX3 and the chemokine decoy receptor D6. / Garlanda, Cecilia; Maina, Virginia; De La Torre, Yeny Martinez; Nebuloni, Manuela; Locati, Massimo.
In: Advances in Neuroimmune Biology, Vol. 2, No. 1-2, 2011, p. 41-50.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Novel players in female fertility
T2 - The long pentraxin PTX3 and the chemokine decoy receptor D6
AU - Garlanda, Cecilia
AU - Maina, Virginia
AU - De La Torre, Yeny Martinez
AU - Nebuloni, Manuela
AU - Locati, Massimo
PY - 2011
Y1 - 2011
N2 - The foetal-maternal interaction results in the induction of a local inflammatory response and a state of systemic inflammation. Several factors are involved in successful embryonic implantation, including hormones, growth factors, cytokines, chemokines, adhesion molecules, extracellular matrix components, and matrix-degrading enzymes. The enriched cytokine milieu associated to implantation is likely to control trophoblast migration and differentiation, leukocyte influx and activation, complement activation, as well as angiogenic and angiostatic processes in the implantation site. Finally, these mediators play a key role in tuning the immune responses to protect the foetus from infections as well as from maternal rejection. Here, the role of two new players involved in regulating inflammation at the maternal-foetal interface will be discussed: the long pentraxin PTX3 and the decoy receptor for inflammatory chemokines D6.
AB - The foetal-maternal interaction results in the induction of a local inflammatory response and a state of systemic inflammation. Several factors are involved in successful embryonic implantation, including hormones, growth factors, cytokines, chemokines, adhesion molecules, extracellular matrix components, and matrix-degrading enzymes. The enriched cytokine milieu associated to implantation is likely to control trophoblast migration and differentiation, leukocyte influx and activation, complement activation, as well as angiogenic and angiostatic processes in the implantation site. Finally, these mediators play a key role in tuning the immune responses to protect the foetus from infections as well as from maternal rejection. Here, the role of two new players involved in regulating inflammation at the maternal-foetal interface will be discussed: the long pentraxin PTX3 and the decoy receptor for inflammatory chemokines D6.
KW - chemokines
KW - decoy receptor
KW - female fertility
KW - inflammation
KW - Pentraxins
UR - http://www.scopus.com/inward/record.url?scp=84860124716&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84860124716&partnerID=8YFLogxK
U2 - 10.3233/NIB-2011-024
DO - 10.3233/NIB-2011-024
M3 - Article
AN - SCOPUS:84860124716
VL - 2
SP - 41
EP - 50
JO - Advances in Neuroimmune Biology
JF - Advances in Neuroimmune Biology
SN - 1878-948X
IS - 1-2
ER -