Novel players in female fertility: The long pentraxin PTX3 and the chemokine decoy receptor D6

Cecilia Garlanda, Virginia Maina, Yeny Martinez De La Torre, Manuela Nebuloni, Massimo Locati

Research output: Contribution to journalArticlepeer-review

Abstract

The foetal-maternal interaction results in the induction of a local inflammatory response and a state of systemic inflammation. Several factors are involved in successful embryonic implantation, including hormones, growth factors, cytokines, chemokines, adhesion molecules, extracellular matrix components, and matrix-degrading enzymes. The enriched cytokine milieu associated to implantation is likely to control trophoblast migration and differentiation, leukocyte influx and activation, complement activation, as well as angiogenic and angiostatic processes in the implantation site. Finally, these mediators play a key role in tuning the immune responses to protect the foetus from infections as well as from maternal rejection. Here, the role of two new players involved in regulating inflammation at the maternal-foetal interface will be discussed: the long pentraxin PTX3 and the decoy receptor for inflammatory chemokines D6.

Original languageEnglish
Pages (from-to)41-50
Number of pages10
JournalAdvances in Neuroimmune Biology
Volume2
Issue number1-2
DOIs
Publication statusPublished - 2011

Keywords

  • chemokines
  • decoy receptor
  • female fertility
  • inflammation
  • Pentraxins

ASJC Scopus subject areas

  • Immunology
  • Endocrine and Autonomic Systems
  • Endocrinology

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