Novel Regulators of the IGF System in Cancer

Research output: Contribution to journalReview articlepeer-review

Abstract

The insulin-like growth factor (IGF) system is a dynamic network of proteins, which includes cognate ligands, membrane receptors, ligand binding proteins and functional downstream effectors. It plays a critical role in regulating several important physiological processes including cell growth, metabolism and differentiation. Importantly, alterations in expression levels or activation of components of the IGF network are implicated in many pathological conditions including diabetes, obesity and cancer initiation and progression. In this review we will initially cover some general aspects of IGF action and regulation in cancer and then focus in particular on the role of transcriptional regulators and novel interacting proteins, which functionally contribute in fine tuning IGF1R signaling in several cancer models. A deeper understanding of the biological relevance of this network of IGF1R modulators might provide novel therapeutic opportunities to block this system in neoplasia.

Original languageEnglish
Pages (from-to)1-19
Number of pages19
JournalBiomolecules
Volume11
Issue number2
DOIs
Publication statusPublished - Feb 12 2021

Keywords

  • ADAR
  • DDR1
  • E-cadherin
  • IGF system
  • IGF2BPs
  • cancer
  • circular RNAs
  • decorin
  • functional regulation
  • transcriptional regulators

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