Novel RNA-binding motif: The KH module

S. Adinolfi, C. Bagni, M. A Castiglione Morelli, F. Fraternali, G. Musco, A. Pastore

Research output: Contribution to journalArticlepeer-review


The KH motif has recently been identified in single or multiple copies in a number of RNA associated proteins. Here we review the current knowledge accumulated about the sequence, structure, and functions of the KH. The multidomain architecture of most of the KH-containing proteins inspired an approach based on the production of peptides spanning the sequence of an isolated KH motif. Correct identification of the minimal length necessary for producing a folded peptide has had a number of important consequences for interpreting functional data. The presence of the KH motifs in fmr1, the protein responsible for the fragile X syndrome, and their possible role in the fmr1 functions are also discussed.

Original languageEnglish
Pages (from-to)153-164
Number of pages12
Issue number2
Publication statusPublished - 1999


  • Fragile X
  • Modular proteins
  • RNA-binding
  • Trinucleotide expansion

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Biophysics


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