Novel soybean/gelatine-based bioactive and injectable hydroxyapatite foam: Material properties and cell response

F. Perut, E. B. Montufar, G. Ciapetti, M. Santin, J. Salvage, T. Traykova, J. A. Planell, M. P. Ginebra, N. Baldini

Research output: Contribution to journalArticle

Abstract

Despite their known osteoconductivity, clinical use of calcium phosphate cements is limited both by their relatively slow rate of resorption and by rheological properties incompatible with injectability. Bone in-growth and material resorption have been improved by the development of porous calcium phosphate cements. However, injectable formulations have so far only been obtained through the addition of relatively toxic surfactants. The present work describes the response of osteoblasts to a novel injectable foamed bone cement based on a composite formulation including the bioactive foaming agents soybean and gelatine. The foaming properties of both defatted soybean and gelatine gels were exploited to develop a self-hardening soy/gelatine/hydroxyapatite composite foam able to retain porosity upon injection. After setting, the foamed paste produced a calcium-deficient hydroxyapatite scaffold, showing good injectability and cohesion as well as interconnected porosity after injection. The intrinsic bioactivity of soybean and gelatine was shown to favour osteoblast adhesion and growth. These findings suggest that injectable, porous and bioactive calcium phosphate cements can be produced for bone regeneration through minimally invasive surgery.

Original languageEnglish
Pages (from-to)1780-1787
Number of pages8
JournalActa Biomaterialia
Volume7
Issue number4
DOIs
Publication statusPublished - Apr 2011

Keywords

  • Bioactivity
  • Bone tissue engineering
  • Calcium phosphate cement
  • Cell viability
  • Composite

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Biotechnology
  • Biochemistry
  • Molecular Biology

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