Novel targets in multiple sclerosis: To oxidative stress and beyond

Research output: Contribution to journalArticle

Abstract

Despite multiple sclerosis (MS) represents one of the most fascinating mystery of modern medicine due to its unknown etiology and the incomplete knowledge of a clear mechanism of pathogenesis, progress against this disease has made giant leaps. Current management of MS takes advantage of many disease- modifying therapeutics of anti-inflammatory and immunomodulatory nature, whose primary aims are halting immune responses during attacks, preventing new attacks and avoiding disability. In this review, a synopsis on effective therapies targeting both immune-mediated responses and neurodegenerative processes is appointed. Oxidative stress has been also implicated in both the inflammatory and neurodegenerative pathological mechanisms underlying MS. The role of redox metabolism in MS is thus also reported, with particular focus on the latest improvements in the identification of oxidative stress as a potential new therapeutic target.

Original languageEnglish
Pages (from-to)2590-2599
Number of pages10
JournalCurrent Topics in Medicinal Chemistry
Volume14
Issue number22
Publication statusPublished - Oct 1 2014

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Multiple Sclerosis
Oxidative Stress
Modern 1601-history
Oxidation-Reduction
Anti-Inflammatory Agents
Therapeutics

Keywords

  • Inflammation
  • Multiple sclerosis
  • Neurodegeneration
  • Oxidative stress
  • Remyelination
  • Therapeutics

ASJC Scopus subject areas

  • Drug Discovery
  • Medicine(all)

Cite this

Novel targets in multiple sclerosis : To oxidative stress and beyond. / Chiurchiù, Valerio.

In: Current Topics in Medicinal Chemistry, Vol. 14, No. 22, 01.10.2014, p. 2590-2599.

Research output: Contribution to journalArticle

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