Novel TEM-type extended-spectrum β-lactamase, TEM-134, in a Citrobacter koseri clinical isolate

Mariagrazia Perilli, Claudia Mugnaioli, Francesco Luzzaro, Marianna Fiore, Stefania Stefani, Gian Maria Rossolini, Gianfranco Amicosante

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A new natural TEM derivative with extended-spectrum β-lactamase activity, TEM-134, was identified in a ceftazidime-resistant clinical isolate of Citrobacter koseri. Compared to TEM-1, TEM-134 contains the following mutations: Q39K, E104K, R164H, and G238S. The blaTEM-134 gene was not transferable by conjugation and, apparently, was chromosomally encoded. Expression studies with Escherichia coli revealed efficient cefotaximase and ceftazidimase activity for TEM-134.

Original languageEnglish
Pages (from-to)1564-1566
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume49
Issue number4
DOIs
Publication statusPublished - Apr 2005

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Citrobacter koseri
Ceftazidime
Escherichia coli
Mutation
Genes
beta-lactamase CTX-2

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Perilli, M., Mugnaioli, C., Luzzaro, F., Fiore, M., Stefani, S., Rossolini, G. M., & Amicosante, G. (2005). Novel TEM-type extended-spectrum β-lactamase, TEM-134, in a Citrobacter koseri clinical isolate. Antimicrobial Agents and Chemotherapy, 49(4), 1564-1566. https://doi.org/10.1128/AAC.49.4.1564-1566.2005

Novel TEM-type extended-spectrum β-lactamase, TEM-134, in a Citrobacter koseri clinical isolate. / Perilli, Mariagrazia; Mugnaioli, Claudia; Luzzaro, Francesco; Fiore, Marianna; Stefani, Stefania; Rossolini, Gian Maria; Amicosante, Gianfranco.

In: Antimicrobial Agents and Chemotherapy, Vol. 49, No. 4, 04.2005, p. 1564-1566.

Research output: Contribution to journalArticle

Perilli, M, Mugnaioli, C, Luzzaro, F, Fiore, M, Stefani, S, Rossolini, GM & Amicosante, G 2005, 'Novel TEM-type extended-spectrum β-lactamase, TEM-134, in a Citrobacter koseri clinical isolate', Antimicrobial Agents and Chemotherapy, vol. 49, no. 4, pp. 1564-1566. https://doi.org/10.1128/AAC.49.4.1564-1566.2005
Perilli, Mariagrazia ; Mugnaioli, Claudia ; Luzzaro, Francesco ; Fiore, Marianna ; Stefani, Stefania ; Rossolini, Gian Maria ; Amicosante, Gianfranco. / Novel TEM-type extended-spectrum β-lactamase, TEM-134, in a Citrobacter koseri clinical isolate. In: Antimicrobial Agents and Chemotherapy. 2005 ; Vol. 49, No. 4. pp. 1564-1566.
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