Novel TEM-type extended-spectrum β-lactamase, TEM-134, in a Citrobacter koseri clinical isolate

Mariagrazia Perilli, Claudia Mugnaioli, Francesco Luzzaro, Marianna Fiore, Stefania Stefani, Gian Maria Rossolini, Gianfranco Amicosante

Research output: Contribution to journalArticlepeer-review

Abstract

A new natural TEM derivative with extended-spectrum β-lactamase activity, TEM-134, was identified in a ceftazidime-resistant clinical isolate of Citrobacter koseri. Compared to TEM-1, TEM-134 contains the following mutations: Q39K, E104K, R164H, and G238S. The blaTEM-134 gene was not transferable by conjugation and, apparently, was chromosomally encoded. Expression studies with Escherichia coli revealed efficient cefotaximase and ceftazidimase activity for TEM-134.

Original languageEnglish
Pages (from-to)1564-1566
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume49
Issue number4
DOIs
Publication statusPublished - Apr 2005

ASJC Scopus subject areas

  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Novel TEM-type extended-spectrum β-lactamase, TEM-134, in a Citrobacter koseri clinical isolate'. Together they form a unique fingerprint.

Cite this