Novel therapeutics in adult malignant brain gliomas

Michele Reni, Elena Mazza, Alicia Tosoni, Alba A. Brandes

Research output: Contribution to journalArticlepeer-review

Abstract

Malignant gliomas are the most frequent and most malignant intracranial neoplasms. In spite of extensive clinical trials and irrespective of aggressive surgery, radiotherapy and chemotherapy, the outcome is very poor and limited progress has been made in the last three decades. Several innovative targeted molecular therapies that are tailored to deregulate the signalling pathways involved in malignant progression have opened new and challenging treatment opportunities and offer hope for an improved outcome in the future. Furthermore, in the field of conventional cytotoxic agents, new drugs or combinations are continuously investigated, widening the therapeutic armamentarium. This paper reviews this rapidly evolving field, focuses on the results of the use of these agents in clinical trials and discusses the main methodological challenges that need to be dealt with before relevant progress in the outcome of malignant gliomas can be yielded.

Original languageEnglish
Pages (from-to)643-657
Number of pages15
JournalExpert Opinion on Investigational Drugs
Volume14
Issue number6
DOIs
Publication statusPublished - Jun 2005

Keywords

  • Anaplastic astrocytoma
  • Angiogenesis
  • Chemotherapy
  • Epidermal growth factor receptor
  • Farnesyltransferase
  • Glioblastoma
  • Metalloproteinase
  • mTOR
  • Platelet-derived growth factor
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Pharmacology

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