The two major neuropathologic hallmarks of Alzheimer's disease (AD) areextracellular Amyloid beta (AΒ ) plaques and intracellular neurofibrillary tangles (NFTs).Several additional pathogenic mechanisms likely play a role in the pathogenesis of thedisease, including inflammation, oxidative damage, ion disregulation and cholesterolmetabolism. A number of compounds have been developed, trying to interfere with theabove mentioned altered mechanisms. Conversely to symptomatic drugs available todate, these new compounds are supposed to modify pathological steps leading to AD,thus acting on the evolution of the disease. Some of them are under clinical testing,others are in preclinical phases of development. In this chapter, the main pathogenicsteps leading to neurodegeneration will be discussed, together with an update ofpotentially disease-modifying drugs under testing.
|Title of host publication||Cognitive Impairment: Causes, Diagnosis and Treatments|
|Publisher||Nova Science Publishers, Inc.|
|Number of pages||24|
|Publication status||Published - Apr 2009|
ASJC Scopus subject areas
- Physics and Astronomy(all)