Novel Tn antigen-containing neoglycopeptides: Synthesis and evaluation as anti tumor vaccines

Laura Cipolla, Maria Rescigno, Antonella Leone, Francesco Peri, Barbara La Ferla, Francesco Nicotra

Research output: Contribution to journalArticlepeer-review

Abstract

The fully unprotected α-C-glycosyl analogue of N-acetylgalactosamine 9 was conjugated by a non-natural oxime bond to the segment peptides 328-340OVA and 327-339OVA, affording neoglycopeptides 1-2 and 3, having one or two sugar units, respectively. The three neoglycopeptides were tested in vitro in an antigen presentation assay as antitumor vaccines. Neoglycopeptides 1-3 could be presented to and recognized by the T cell receptor; neoglycopeptide 3, bearing two B-epitopes, was presented to the TCR with higher efficiency, compared to neoglycopeptide 2, having only one B-epitope.

Original languageEnglish
Pages (from-to)1639-1646
Number of pages8
JournalBioorganic and Medicinal Chemistry
Volume10
Issue number5
DOIs
Publication statusPublished - 2002

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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