Abstract
There is strong epidemiological evidence that air pollution exposure (short- and long-term, i.e. <24 hr to 3 weeks, and year/s) is related to exacerbation of cardiovascular and respiratory diseases. Data from toxicological and basic science/molecular studies, controlled animal and human exposures and human panel studies have demonstrated several mechanisms by which particle exposure may both trigger acute events as well as prompt the chronic development of cardiovascular diseases. These pollutant-mediated biological mechanisms are supporting the potential use of haematic (inflammation!coagulation!oxidative stress) markers of effects in cardio-respiratory diseases. Various examples from in vitro, in vivo and epidemiological investigations are reported, together with some novel technologies that should provide with new tools for research in these diseases and improve the knowledge about any linkage of local and systemic inflammation and clinical features of these diseases (in particular COPD), including lung function, exacerbations, disease progression, and mortality.
| Original language | English |
|---|---|
| Pages (from-to) | 175-186 |
| Number of pages | 12 |
| Journal | Giornale Italiano di Medicina del Lavoro ed Ergonomia |
| Volume | 34 |
| Issue number | 2 |
| Publication status | Published - Apr 2012 |
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Keywords
- Air pollutants
- Blood markers
- Inflammation
- Microarray technology
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
Cite this
Novel tools (or blood inflammatory markers detection in monitoring air pollution-induced cardio-respiratory symptoms. / Coccini, Teresa; Manzo, Luigi; De Simone, Uliana; Acerbi, Davide; Roda, Elisa.
In: Giornale Italiano di Medicina del Lavoro ed Ergonomia, Vol. 34, No. 2, 04.2012, p. 175-186.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Novel tools (or blood inflammatory markers detection in monitoring air pollution-induced cardio-respiratory symptoms
AU - Coccini, Teresa
AU - Manzo, Luigi
AU - De Simone, Uliana
AU - Acerbi, Davide
AU - Roda, Elisa
PY - 2012/4
Y1 - 2012/4
N2 - There is strong epidemiological evidence that air pollution exposure (short- and long-term, i.e. <24 hr to 3 weeks, and year/s) is related to exacerbation of cardiovascular and respiratory diseases. Data from toxicological and basic science/molecular studies, controlled animal and human exposures and human panel studies have demonstrated several mechanisms by which particle exposure may both trigger acute events as well as prompt the chronic development of cardiovascular diseases. These pollutant-mediated biological mechanisms are supporting the potential use of haematic (inflammation!coagulation!oxidative stress) markers of effects in cardio-respiratory diseases. Various examples from in vitro, in vivo and epidemiological investigations are reported, together with some novel technologies that should provide with new tools for research in these diseases and improve the knowledge about any linkage of local and systemic inflammation and clinical features of these diseases (in particular COPD), including lung function, exacerbations, disease progression, and mortality.
AB - There is strong epidemiological evidence that air pollution exposure (short- and long-term, i.e. <24 hr to 3 weeks, and year/s) is related to exacerbation of cardiovascular and respiratory diseases. Data from toxicological and basic science/molecular studies, controlled animal and human exposures and human panel studies have demonstrated several mechanisms by which particle exposure may both trigger acute events as well as prompt the chronic development of cardiovascular diseases. These pollutant-mediated biological mechanisms are supporting the potential use of haematic (inflammation!coagulation!oxidative stress) markers of effects in cardio-respiratory diseases. Various examples from in vitro, in vivo and epidemiological investigations are reported, together with some novel technologies that should provide with new tools for research in these diseases and improve the knowledge about any linkage of local and systemic inflammation and clinical features of these diseases (in particular COPD), including lung function, exacerbations, disease progression, and mortality.
KW - Air pollutants
KW - Blood markers
KW - Inflammation
KW - Microarray technology
UR - http://www.scopus.com/inward/record.url?scp=84864220984&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84864220984&partnerID=8YFLogxK
M3 - Article
C2 - 22888728
AN - SCOPUS:84864220984
VL - 34
SP - 175
EP - 186
JO - Giornale Italiano di Medicina del Lavoro ed Ergonomia
JF - Giornale Italiano di Medicina del Lavoro ed Ergonomia
SN - 1592-7830
IS - 2
ER -