Novel tools (or blood inflammatory markers detection in monitoring air pollution-induced cardio-respiratory symptoms

Teresa Coccini, Luigi Manzo, Uliana De Simone, Davide Acerbi, Elisa Roda

Research output: Contribution to journalArticle

Abstract

There is strong epidemiological evidence that air pollution exposure (short- and long-term, i.e. <24 hr to 3 weeks, and year/s) is related to exacerbation of cardiovascular and respiratory diseases. Data from toxicological and basic science/molecular studies, controlled animal and human exposures and human panel studies have demonstrated several mechanisms by which particle exposure may both trigger acute events as well as prompt the chronic development of cardiovascular diseases. These pollutant-mediated biological mechanisms are supporting the potential use of haematic (inflammation!coagulation!oxidative stress) markers of effects in cardio-respiratory diseases. Various examples from in vitro, in vivo and epidemiological investigations are reported, together with some novel technologies that should provide with new tools for research in these diseases and improve the knowledge about any linkage of local and systemic inflammation and clinical features of these diseases (in particular COPD), including lung function, exacerbations, disease progression, and mortality.

Original languageEnglish
Pages (from-to)175-186
Number of pages12
JournalGiornale Italiano di Medicina del Lavoro ed Ergonomia
Volume34
Issue number2
Publication statusPublished - Apr 2012

Fingerprint

Air Pollution
Cardiovascular Diseases
Inflammation
Toxicology
Chronic Obstructive Pulmonary Disease
Disease Progression
Oxidative Stress
Technology
Lung
Mortality
Research

Keywords

  • Air pollutants
  • Blood markers
  • Inflammation
  • Microarray technology

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Novel tools (or blood inflammatory markers detection in monitoring air pollution-induced cardio-respiratory symptoms. / Coccini, Teresa; Manzo, Luigi; De Simone, Uliana; Acerbi, Davide; Roda, Elisa.

In: Giornale Italiano di Medicina del Lavoro ed Ergonomia, Vol. 34, No. 2, 04.2012, p. 175-186.

Research output: Contribution to journalArticle

@article{f3a598c9065d4779b890d0ffcdbd36df,
title = "Novel tools (or blood inflammatory markers detection in monitoring air pollution-induced cardio-respiratory symptoms",
abstract = "There is strong epidemiological evidence that air pollution exposure (short- and long-term, i.e. <24 hr to 3 weeks, and year/s) is related to exacerbation of cardiovascular and respiratory diseases. Data from toxicological and basic science/molecular studies, controlled animal and human exposures and human panel studies have demonstrated several mechanisms by which particle exposure may both trigger acute events as well as prompt the chronic development of cardiovascular diseases. These pollutant-mediated biological mechanisms are supporting the potential use of haematic (inflammation!coagulation!oxidative stress) markers of effects in cardio-respiratory diseases. Various examples from in vitro, in vivo and epidemiological investigations are reported, together with some novel technologies that should provide with new tools for research in these diseases and improve the knowledge about any linkage of local and systemic inflammation and clinical features of these diseases (in particular COPD), including lung function, exacerbations, disease progression, and mortality.",
keywords = "Air pollutants, Blood markers, Inflammation, Microarray technology",
author = "Teresa Coccini and Luigi Manzo and {De Simone}, Uliana and Davide Acerbi and Elisa Roda",
year = "2012",
month = "4",
language = "English",
volume = "34",
pages = "175--186",
journal = "Giornale Italiano di Medicina del Lavoro ed Ergonomia",
issn = "1592-7830",
publisher = "Tipografia PI-ME Editrice Srl",
number = "2",

}

TY - JOUR

T1 - Novel tools (or blood inflammatory markers detection in monitoring air pollution-induced cardio-respiratory symptoms

AU - Coccini, Teresa

AU - Manzo, Luigi

AU - De Simone, Uliana

AU - Acerbi, Davide

AU - Roda, Elisa

PY - 2012/4

Y1 - 2012/4

N2 - There is strong epidemiological evidence that air pollution exposure (short- and long-term, i.e. <24 hr to 3 weeks, and year/s) is related to exacerbation of cardiovascular and respiratory diseases. Data from toxicological and basic science/molecular studies, controlled animal and human exposures and human panel studies have demonstrated several mechanisms by which particle exposure may both trigger acute events as well as prompt the chronic development of cardiovascular diseases. These pollutant-mediated biological mechanisms are supporting the potential use of haematic (inflammation!coagulation!oxidative stress) markers of effects in cardio-respiratory diseases. Various examples from in vitro, in vivo and epidemiological investigations are reported, together with some novel technologies that should provide with new tools for research in these diseases and improve the knowledge about any linkage of local and systemic inflammation and clinical features of these diseases (in particular COPD), including lung function, exacerbations, disease progression, and mortality.

AB - There is strong epidemiological evidence that air pollution exposure (short- and long-term, i.e. <24 hr to 3 weeks, and year/s) is related to exacerbation of cardiovascular and respiratory diseases. Data from toxicological and basic science/molecular studies, controlled animal and human exposures and human panel studies have demonstrated several mechanisms by which particle exposure may both trigger acute events as well as prompt the chronic development of cardiovascular diseases. These pollutant-mediated biological mechanisms are supporting the potential use of haematic (inflammation!coagulation!oxidative stress) markers of effects in cardio-respiratory diseases. Various examples from in vitro, in vivo and epidemiological investigations are reported, together with some novel technologies that should provide with new tools for research in these diseases and improve the knowledge about any linkage of local and systemic inflammation and clinical features of these diseases (in particular COPD), including lung function, exacerbations, disease progression, and mortality.

KW - Air pollutants

KW - Blood markers

KW - Inflammation

KW - Microarray technology

UR - http://www.scopus.com/inward/record.url?scp=84864220984&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84864220984&partnerID=8YFLogxK

M3 - Article

C2 - 22888728

AN - SCOPUS:84864220984

VL - 34

SP - 175

EP - 186

JO - Giornale Italiano di Medicina del Lavoro ed Ergonomia

JF - Giornale Italiano di Medicina del Lavoro ed Ergonomia

SN - 1592-7830

IS - 2

ER -