Novel tools (or blood inflammatory markers detection in monitoring air pollution-induced cardio-respiratory symptoms

Teresa Coccini, Luigi Manzo, Uliana De Simone, Davide Acerbi, Elisa Roda

Research output: Contribution to journalArticle

Abstract

There is strong epidemiological evidence that air pollution exposure (short- and long-term, i.e. <24 hr to 3 weeks, and year/s) is related to exacerbation of cardiovascular and respiratory diseases. Data from toxicological and basic science/molecular studies, controlled animal and human exposures and human panel studies have demonstrated several mechanisms by which particle exposure may both trigger acute events as well as prompt the chronic development of cardiovascular diseases. These pollutant-mediated biological mechanisms are supporting the potential use of haematic (inflammation!coagulation!oxidative stress) markers of effects in cardio-respiratory diseases. Various examples from in vitro, in vivo and epidemiological investigations are reported, together with some novel technologies that should provide with new tools for research in these diseases and improve the knowledge about any linkage of local and systemic inflammation and clinical features of these diseases (in particular COPD), including lung function, exacerbations, disease progression, and mortality.

Original languageEnglish
Pages (from-to)175-186
Number of pages12
JournalGiornale Italiano di Medicina del Lavoro ed Ergonomia
Volume34
Issue number2
Publication statusPublished - Apr 2012

    Fingerprint

Keywords

  • Air pollutants
  • Blood markers
  • Inflammation
  • Microarray technology

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this