Novel treatment strategies for early-stage lung cancer: The oncologist’s perspective

Research output: Contribution to journalReview articlepeer-review

Abstract

Management of early-stage non-small cell lung cancer (NSCLC) consists in multimodal treatment, including surgery, radiotherapy and chemotherapy. The mainstay of treatment is radical surgery. Definitive radiotherapy using stereotactic techniques can provide adequate local disease control, and is the treatment of choice in medically inoperable patients. Most early-stage patients are at significant risk of disease relapse after local treatment. Adjuvant platinum-based chemotherapy has demonstrated to provide an absolute survival benefit of 5% compared to observation. However, unlike advanced/metastatic disease, little progress has been made in the treatment of early-stage NSCLC over the past decade. In recent years, plenty of research has focused on the optimization of adjuvant and neoadjuvant treatment. Several trials with novel drugs, such as targeted agents and immune-checkpoint inhibitors are currently underway, with preliminary positive results. Customization of treatment on patients’ characteristics before, and major pathological response after therapy, will further improve survival outcomes in this subset of patients.

Original languageEnglish
Pages (from-to)3390-3398
Number of pages9
JournalJournal of Thoracic Disease
Volume12
Issue number6
DOIs
Publication statusPublished - Jun 1 2020

Keywords

  • Adjuvant
  • Early-stage
  • Immune checkpoint inhibitors (ICIs)
  • Neoadjuvant
  • Non-small cell lung cancer (NSCLC)

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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