Novel Tween® 20 derivatives enable the formation of efficient pH-sensitive drug delivery vehicles for human hepatoblastoma

Andrea Masotti, Paola Vicennati, Anna Alisi, Carlotta Marianecci, Federica Rinaldi, Maria Carafa, Giancarlo Ortaggi

Research output: Contribution to journalArticlepeer-review

Abstract

We describe the synthesis, the physicochemical characterization and the biological evaluation of three novel pH-sensitive systems prepared derivatizing polysorbate 20 (Tween® 20) with glycine, N-methyl-glycine and N,N-dimethyl-glycine (TW20-GLY, TW20-MMG and TW20-DMG). These derivatives form pH-sensitive vesicles and translocate small molecules into cells. The reported systems are efficient drug delivery systems for human hepatoblastoma cells.

Original languageEnglish
Pages (from-to)3021-3025
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume20
Issue number10
DOIs
Publication statusPublished - May 15 2010

Keywords

  • Drug delivery systems
  • Hepatoblastoma
  • pH-sensitive vesicles
  • Tween® 20

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry
  • Medicine(all)

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