TY - JOUR
T1 - Novel type of chronic wasting disease detected in moose (Alces alces), Norway
AU - Pirisinu, Laura
AU - Tran, Linh
AU - Chiappini, Barbara
AU - Vanni, Ilaria
AU - Di Bari, Michele A.
AU - Vaccari, Gabriele
AU - Vikøren, Turid
AU - Madslien, Knut Ivar
AU - Våge, Jørn
AU - Spraker, Terry
AU - Mitchell, Gordon
AU - Balachandran, Aru
AU - Baron, Thierry
AU - Casalone, Cristina
AU - Rolandsen, Christer M.
AU - Røed, Knut H.
AU - Agrimi, Umberto
AU - Nonno, Romolo
AU - Benestad, Sylvie L.
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Chronic wasting disease (CWD) persists in cervid populations of North America and in 2016 was detected for the first time in Europe in a wild reindeer in Norway. We report the detection of CWD in 3 moose (Alces alces) in Norway, identified through a large-scale surveillance program. The cases occurred in 13–14-year-old female moose, and we detected an abnormal form of prion protein (PrPSc) in the brain but not in lymphoid tissues. Immunohistochemistry revealed that the moose shared the same neuropathologic phenotype, characterized by mostly intraneuronal deposition of PrPSc. This pattern differed from that observed in reindeer and has not been previously reported in CWD-infected cervids. Moreover, Western blot revealed a PrPSc type distinguishable from previous CWD cases and from known ruminant prion diseases in Europe, with the possible exception of sheep CH1641. These findings suggest that these cases in moose represent a novel type of CWD.
AB - Chronic wasting disease (CWD) persists in cervid populations of North America and in 2016 was detected for the first time in Europe in a wild reindeer in Norway. We report the detection of CWD in 3 moose (Alces alces) in Norway, identified through a large-scale surveillance program. The cases occurred in 13–14-year-old female moose, and we detected an abnormal form of prion protein (PrPSc) in the brain but not in lymphoid tissues. Immunohistochemistry revealed that the moose shared the same neuropathologic phenotype, characterized by mostly intraneuronal deposition of PrPSc. This pattern differed from that observed in reindeer and has not been previously reported in CWD-infected cervids. Moreover, Western blot revealed a PrPSc type distinguishable from previous CWD cases and from known ruminant prion diseases in Europe, with the possible exception of sheep CH1641. These findings suggest that these cases in moose represent a novel type of CWD.
UR - http://www.scopus.com/inward/record.url?scp=85056710737&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85056710737&partnerID=8YFLogxK
U2 - 10.3201/eid2412.180702
DO - 10.3201/eid2412.180702
M3 - Article
C2 - 30457526
AN - SCOPUS:85056710737
VL - 24
SP - 2210
EP - 2218
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
SN - 1080-6040
IS - 12
ER -