Novel type of chronic wasting disease detected in moose (Alces alces), Norway

Laura Pirisinu; Linh Tran; Barbara Chiappini; Ilaria Vanni; Michele A. Di Bari; Gabriele Vaccari; Turid Vikøren; Knut Ivar Madslien; Jørn Våge; Terry Spraker; Gordon Mitchell; Aru Balachandran; Thierry Baron; Cristina Casalone; Christer M. Rolandsen; Knut H. Røed; Umberto Agrimi; Romolo Nonno; Sylvie L. Benestad

doi:10.3201/eid2412.180702

Novel type of chronic wasting disease detected in moose (Alces alces), Norway

Laura Pirisinu, Linh Tran, Barbara Chiappini, Ilaria Vanni, Michele A. Di Bari, Gabriele Vaccari, Turid Vikøren, Knut Ivar Madslien, Jørn Våge, Terry Spraker, Gordon Mitchell, Aru Balachandran, Thierry Baron, Cristina Casalone, Christer M. Rolandsen, Knut H. Røed, Umberto Agrimi, Romolo Nonno, Sylvie L. Benestad

Istituto Superiore di Sanita'

Research output: Contribution to journal › Article › peer-review

Abstract

Chronic wasting disease (CWD) persists in cervid populations of North America and in 2016 was detected for the first time in Europe in a wild reindeer in Norway. We report the detection of CWD in 3 moose (Alces alces) in Norway, identified through a large-scale surveillance program. The cases occurred in 13–14-year-old female moose, and we detected an abnormal form of prion protein (PrP^Sc) in the brain but not in lymphoid tissues. Immunohistochemistry revealed that the moose shared the same neuropathologic phenotype, characterized by mostly intraneuronal deposition of PrP^Sc. This pattern differed from that observed in reindeer and has not been previously reported in CWD-infected cervids. Moreover, Western blot revealed a PrP^Sc type distinguishable from previous CWD cases and from known ruminant prion diseases in Europe, with the possible exception of sheep CH1641. These findings suggest that these cases in moose represent a novel type of CWD.

Original language	English
Pages (from-to)	2210-2218
Number of pages	9
Journal	Emerging Infectious Diseases
Volume	24
Issue number	12
DOIs	https://doi.org/10.3201/eid2412.180702
Publication status	Published - Dec 1 2018

ASJC Scopus subject areas

Epidemiology
Microbiology (medical)
Infectious Diseases

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Pirisinu, L., Tran, L., Chiappini, B., Vanni, I., Di Bari, M. A., Vaccari, G., Vikøren, T., Madslien, K. I., Våge, J., Spraker, T., Mitchell, G., Balachandran, A., Baron, T., Casalone, C., Rolandsen, C. M., Røed, K. H., Agrimi, U., Nonno, R., & Benestad, S. L. (2018). Novel type of chronic wasting disease detected in moose (Alces alces), Norway. Emerging Infectious Diseases, 24(12), 2210-2218. https://doi.org/10.3201/eid2412.180702

Novel type of chronic wasting disease detected in moose (Alces alces), Norway. / Pirisinu, Laura; Tran, Linh; Chiappini, Barbara; Vanni, Ilaria ; Di Bari, Michele A.; Vaccari, Gabriele; Vikøren, Turid; Madslien, Knut Ivar; Våge, Jørn; Spraker, Terry; Mitchell, Gordon; Balachandran, Aru; Baron, Thierry; Casalone, Cristina; Rolandsen, Christer M.; Røed, Knut H.; Agrimi, Umberto ; Nonno, Romolo; Benestad, Sylvie L.

In: Emerging Infectious Diseases, Vol. 24, No. 12, 01.12.2018, p. 2210-2218.

Research output: Contribution to journal › Article › peer-review

Pirisinu, L, Tran, L, Chiappini, B, Vanni, I , Di Bari, MA , Vaccari, G, Vikøren, T, Madslien, KI, Våge, J, Spraker, T, Mitchell, G, Balachandran, A, Baron, T, Casalone, C, Rolandsen, CM, Røed, KH, Agrimi, U , Nonno, R & Benestad, SL 2018, 'Novel type of chronic wasting disease detected in moose (Alces alces), Norway', Emerging Infectious Diseases, vol. 24, no. 12, pp. 2210-2218. https://doi.org/10.3201/eid2412.180702

Pirisinu, Laura ; Tran, Linh ; Chiappini, Barbara ; Vanni, Ilaria ; Di Bari, Michele A. ; Vaccari, Gabriele ; Vikøren, Turid ; Madslien, Knut Ivar ; Våge, Jørn ; Spraker, Terry ; Mitchell, Gordon ; Balachandran, Aru ; Baron, Thierry ; Casalone, Cristina ; Rolandsen, Christer M. ; Røed, Knut H. ; Agrimi, Umberto ; Nonno, Romolo ; Benestad, Sylvie L. / Novel type of chronic wasting disease detected in moose (Alces alces), Norway. In: Emerging Infectious Diseases. 2018 ; Vol. 24, No. 12. pp. 2210-2218.

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abstract = "Chronic wasting disease (CWD) persists in cervid populations of North America and in 2016 was detected for the first time in Europe in a wild reindeer in Norway. We report the detection of CWD in 3 moose (Alces alces) in Norway, identified through a large-scale surveillance program. The cases occurred in 13–14-year-old female moose, and we detected an abnormal form of prion protein (PrPSc) in the brain but not in lymphoid tissues. Immunohistochemistry revealed that the moose shared the same neuropathologic phenotype, characterized by mostly intraneuronal deposition of PrPSc. This pattern differed from that observed in reindeer and has not been previously reported in CWD-infected cervids. Moreover, Western blot revealed a PrPSc type distinguishable from previous CWD cases and from known ruminant prion diseases in Europe, with the possible exception of sheep CH1641. These findings suggest that these cases in moose represent a novel type of CWD.",

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