Novel types of carborane-carrier hyaluronan derivatives via "click chemistry"

Chiara di Meo, Luigi Panza, Federica Campo, Donatella Capitani, Luisa Mannina, Alessandra Banzato, Maria Rondina, Antonio Rosato, Vittorio Crescenzi

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Two new HA derivatives bearing carborane rings were synthesized by click chemistry. The optimal conditions were assessed for the preparation of biocompatible boron carriers, potentially suitable for application in BNCT and capable of targeting the CD44 antigen. The new polymeric samples were characterized by means of NMR-spectroscopy techniques that gave degrees of 17 and 8% for HAAACB and HapACB, respectively. Both HAAACB and HApACB turned out to be nontoxic for colorectal, ovarian and bladder tumor cell lines, to disclose a specific interaction with the CD44 antigen as the native hyaluronan moiety, and to deliver boron-atom concentrations largely sufficient for BNCT therapy when accumulated in cancer cells. A graph is presented.

Original languageEnglish
Pages (from-to)670-681
Number of pages12
JournalMacromolecular Bioscience
Volume8
Issue number7
DOIs
Publication statusPublished - Jul 7 2008

Fingerprint

CD44 Antigens
Click Chemistry
Boron
Hyaluronic Acid
Antigens
Bearings (structural)
Cells
Derivatives
Tumor Cell Line
Urinary Bladder Neoplasms
Nuclear magnetic resonance spectroscopy
Tumors
Colorectal Neoplasms
Magnetic Resonance Spectroscopy
Atoms
Neoplasms
Therapeutics

Keywords

  • Biological applications of polymers
  • BNCT
  • Click chemistry
  • Conjugated polymers
  • Hyaluronan

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

Cite this

di Meo, C., Panza, L., Campo, F., Capitani, D., Mannina, L., Banzato, A., ... Crescenzi, V. (2008). Novel types of carborane-carrier hyaluronan derivatives via "click chemistry". Macromolecular Bioscience, 8(7), 670-681. https://doi.org/10.1002/mabi.200700304

Novel types of carborane-carrier hyaluronan derivatives via "click chemistry". / di Meo, Chiara; Panza, Luigi; Campo, Federica; Capitani, Donatella; Mannina, Luisa; Banzato, Alessandra; Rondina, Maria; Rosato, Antonio; Crescenzi, Vittorio.

In: Macromolecular Bioscience, Vol. 8, No. 7, 07.07.2008, p. 670-681.

Research output: Contribution to journalArticle

di Meo, C, Panza, L, Campo, F, Capitani, D, Mannina, L, Banzato, A, Rondina, M, Rosato, A & Crescenzi, V 2008, 'Novel types of carborane-carrier hyaluronan derivatives via "click chemistry"', Macromolecular Bioscience, vol. 8, no. 7, pp. 670-681. https://doi.org/10.1002/mabi.200700304
di Meo C, Panza L, Campo F, Capitani D, Mannina L, Banzato A et al. Novel types of carborane-carrier hyaluronan derivatives via "click chemistry". Macromolecular Bioscience. 2008 Jul 7;8(7):670-681. https://doi.org/10.1002/mabi.200700304
di Meo, Chiara ; Panza, Luigi ; Campo, Federica ; Capitani, Donatella ; Mannina, Luisa ; Banzato, Alessandra ; Rondina, Maria ; Rosato, Antonio ; Crescenzi, Vittorio. / Novel types of carborane-carrier hyaluronan derivatives via "click chemistry". In: Macromolecular Bioscience. 2008 ; Vol. 8, No. 7. pp. 670-681.
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