NREM sleep architecture and relation to GH/IGF-1 axis in laron syndrome

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Laron syndrome (LS), known as growth hormone (GH) receptor deficiency, is a rare form of inherited GH resistance. Sleep disorders were described as a common feature of adult LS patients, while no data are available in children. Bi-directional interactions between human sleep and the somatotropic system were previously described, mainly between slow wave sleep and the nocturnal GH surge. Aims: To analyze the sleep macro-and microstructure in LS and to evaluate the influence of substitutive insulin-like growth factor 1 (IGF-1) therapy on it. Methods: Two young LS females underwent polysomnography; the first study was performed during IGF-1 therapy, the second one after a 3-month wash-out period. Results: In both patients, the sleep macrostructure showed that time in bed, sleep period time, total sleep time, sleep efficiency and rapid eye movement (REM) percentage were all increased during wash-out. The sleep microstructure (cyclic alternating pattern: CAP) showed significantly higher EEG slow oscillations (A1%) in NREM sleep, both during IGF-1 therapy and wash-out. Conclusions: Sleep macrostructure in LS children is slightly affected by substitutive IGF-1 therapy. Sleep microstructure shows an increase of A1%, probably related to abnormally high hypothalamic GHRH secretion, due to GH insensitivity.

Original languageEnglish
Pages (from-to)414-419
Number of pages6
JournalHormone Research in Paediatrics
Volume73
Issue number5
DOIs
Publication statusPublished - Apr 2010

Fingerprint

Laron Syndrome
Somatomedins
Growth Hormone
Sleep
Polysomnography
REM Sleep
Therapeutics

Keywords

  • Cyclic alternating pattern
  • Growth hormone
  • Laron syndrome

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Pediatrics, Perinatology, and Child Health

Cite this

NREM sleep architecture and relation to GH/IGF-1 axis in laron syndrome. / Verrillo, Elisabetta; Bizzarri, Carla; Cappa, Marco; Bruni, Oliviero; Pavone, Martino; Cutrera, Renato.

In: Hormone Research in Paediatrics, Vol. 73, No. 5, 04.2010, p. 414-419.

Research output: Contribution to journalArticle

@article{1982215632f34b619421feadbd7c323a,
title = "NREM sleep architecture and relation to GH/IGF-1 axis in laron syndrome",
abstract = "Background: Laron syndrome (LS), known as growth hormone (GH) receptor deficiency, is a rare form of inherited GH resistance. Sleep disorders were described as a common feature of adult LS patients, while no data are available in children. Bi-directional interactions between human sleep and the somatotropic system were previously described, mainly between slow wave sleep and the nocturnal GH surge. Aims: To analyze the sleep macro-and microstructure in LS and to evaluate the influence of substitutive insulin-like growth factor 1 (IGF-1) therapy on it. Methods: Two young LS females underwent polysomnography; the first study was performed during IGF-1 therapy, the second one after a 3-month wash-out period. Results: In both patients, the sleep macrostructure showed that time in bed, sleep period time, total sleep time, sleep efficiency and rapid eye movement (REM) percentage were all increased during wash-out. The sleep microstructure (cyclic alternating pattern: CAP) showed significantly higher EEG slow oscillations (A1{\%}) in NREM sleep, both during IGF-1 therapy and wash-out. Conclusions: Sleep macrostructure in LS children is slightly affected by substitutive IGF-1 therapy. Sleep microstructure shows an increase of A1{\%}, probably related to abnormally high hypothalamic GHRH secretion, due to GH insensitivity.",
keywords = "Cyclic alternating pattern, Growth hormone, Laron syndrome",
author = "Elisabetta Verrillo and Carla Bizzarri and Marco Cappa and Oliviero Bruni and Martino Pavone and Renato Cutrera",
year = "2010",
month = "4",
doi = "10.1159/000308177",
language = "English",
volume = "73",
pages = "414--419",
journal = "Hormone Research in Paediatrics",
issn = "1663-2818",
publisher = "S. Karger AG",
number = "5",

}

TY - JOUR

T1 - NREM sleep architecture and relation to GH/IGF-1 axis in laron syndrome

AU - Verrillo, Elisabetta

AU - Bizzarri, Carla

AU - Cappa, Marco

AU - Bruni, Oliviero

AU - Pavone, Martino

AU - Cutrera, Renato

PY - 2010/4

Y1 - 2010/4

N2 - Background: Laron syndrome (LS), known as growth hormone (GH) receptor deficiency, is a rare form of inherited GH resistance. Sleep disorders were described as a common feature of adult LS patients, while no data are available in children. Bi-directional interactions between human sleep and the somatotropic system were previously described, mainly between slow wave sleep and the nocturnal GH surge. Aims: To analyze the sleep macro-and microstructure in LS and to evaluate the influence of substitutive insulin-like growth factor 1 (IGF-1) therapy on it. Methods: Two young LS females underwent polysomnography; the first study was performed during IGF-1 therapy, the second one after a 3-month wash-out period. Results: In both patients, the sleep macrostructure showed that time in bed, sleep period time, total sleep time, sleep efficiency and rapid eye movement (REM) percentage were all increased during wash-out. The sleep microstructure (cyclic alternating pattern: CAP) showed significantly higher EEG slow oscillations (A1%) in NREM sleep, both during IGF-1 therapy and wash-out. Conclusions: Sleep macrostructure in LS children is slightly affected by substitutive IGF-1 therapy. Sleep microstructure shows an increase of A1%, probably related to abnormally high hypothalamic GHRH secretion, due to GH insensitivity.

AB - Background: Laron syndrome (LS), known as growth hormone (GH) receptor deficiency, is a rare form of inherited GH resistance. Sleep disorders were described as a common feature of adult LS patients, while no data are available in children. Bi-directional interactions between human sleep and the somatotropic system were previously described, mainly between slow wave sleep and the nocturnal GH surge. Aims: To analyze the sleep macro-and microstructure in LS and to evaluate the influence of substitutive insulin-like growth factor 1 (IGF-1) therapy on it. Methods: Two young LS females underwent polysomnography; the first study was performed during IGF-1 therapy, the second one after a 3-month wash-out period. Results: In both patients, the sleep macrostructure showed that time in bed, sleep period time, total sleep time, sleep efficiency and rapid eye movement (REM) percentage were all increased during wash-out. The sleep microstructure (cyclic alternating pattern: CAP) showed significantly higher EEG slow oscillations (A1%) in NREM sleep, both during IGF-1 therapy and wash-out. Conclusions: Sleep macrostructure in LS children is slightly affected by substitutive IGF-1 therapy. Sleep microstructure shows an increase of A1%, probably related to abnormally high hypothalamic GHRH secretion, due to GH insensitivity.

KW - Cyclic alternating pattern

KW - Growth hormone

KW - Laron syndrome

UR - http://www.scopus.com/inward/record.url?scp=77954060290&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77954060290&partnerID=8YFLogxK

U2 - 10.1159/000308177

DO - 10.1159/000308177

M3 - Article

C2 - 20389115

AN - SCOPUS:77954060290

VL - 73

SP - 414

EP - 419

JO - Hormone Research in Paediatrics

JF - Hormone Research in Paediatrics

SN - 1663-2818

IS - 5

ER -