NT-proBNP, IGF-I and survival in patients with chronic heart failure

Mario Petretta, Annamaria Colao, Celestino Sardu, Franco Scopacasa, Paolo Marzullo, Rosario Pivonello, Luca Fontanella, Maurizio de Caterina, Adriano de Simone, Domenico Bonaduce

Research output: Contribution to journalArticle

Abstract

Objective: Growth hormone (GH) resistance with a reduction of insulin-like growth factor-I (IGF-I) serum concentrations seems to be implicated in the catabolic process associated with chronic heart failure (CHF). However, data concerning the prognostic value of these alterations in CHF patients without cachexia are scant. In this study, we aimed to determine in CHF patients the prognostic value of IGF-I/GH ratio and its relationships with N-terminal brain natriuretic peptide (NT-proBNP), a known marker of prognosis in these patients. Design: We enrolled 82 non-cachectic patients, mean age 61 ± 13 years, with ejection fraction

Original languageEnglish
Pages (from-to)288-296
Number of pages9
JournalGrowth Hormone and IGF Research
Volume17
Issue number4
DOIs
Publication statusPublished - Aug 2007

Keywords

  • Chronic heart failure
  • GH
  • IGF-I
  • NT-proBNP
  • Prognosis

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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    Petretta, M., Colao, A., Sardu, C., Scopacasa, F., Marzullo, P., Pivonello, R., Fontanella, L., de Caterina, M., de Simone, A., & Bonaduce, D. (2007). NT-proBNP, IGF-I and survival in patients with chronic heart failure. Growth Hormone and IGF Research, 17(4), 288-296. https://doi.org/10.1016/j.ghir.2007.01.020