NT-proBNP, IGF-I and survival in patients with chronic heart failure

Mario Petretta; Annamaria Colao; Celestino Sardu; Franco Scopacasa; Paolo Marzullo; Rosario Pivonello; Luca Fontanella; Maurizio de Caterina; Adriano de Simone; Domenico Bonaduce

doi:10.1016/j.ghir.2007.01.020

NT-proBNP, IGF-I and survival in patients with chronic heart failure

Mario Petretta, Annamaria Colao, Celestino Sardu, Franco Scopacasa, Paolo Marzullo, Rosario Pivonello, Luca Fontanella, Maurizio de Caterina, Adriano de Simone, Domenico Bonaduce

Fondazione Istituto Auxologico Italiano

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: Growth hormone (GH) resistance with a reduction of insulin-like growth factor-I (IGF-I) serum concentrations seems to be implicated in the catabolic process associated with chronic heart failure (CHF). However, data concerning the prognostic value of these alterations in CHF patients without cachexia are scant. In this study, we aimed to determine in CHF patients the prognostic value of IGF-I/GH ratio and its relationships with N-terminal brain natriuretic peptide (NT-proBNP), a known marker of prognosis in these patients. Design: We enrolled 82 non-cachectic patients, mean age 61 ± 13 years, with ejection fraction

Original language	English
Pages (from-to)	288-296
Number of pages	9
Journal	Growth Hormone and IGF Research
Volume	17
Issue number	4
DOIs	https://doi.org/10.1016/j.ghir.2007.01.020
Publication status	Published - Aug 2007

Keywords

Chronic heart failure
GH
IGF-I
NT-proBNP
Prognosis

ASJC Scopus subject areas

Endocrinology
Endocrinology, Diabetes and Metabolism

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10.1016/j.ghir.2007.01.020

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NT-proBNP, IGF-I and survival in patients with chronic heart failure. / Petretta, Mario; Colao, Annamaria; Sardu, Celestino; Scopacasa, Franco; Marzullo, Paolo; Pivonello, Rosario; Fontanella, Luca; de Caterina, Maurizio; de Simone, Adriano; Bonaduce, Domenico.

In: Growth Hormone and IGF Research, Vol. 17, No. 4, 08.2007, p. 288-296.

Research output: Contribution to journal › Article › peer-review

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title = "NT-proBNP, IGF-I and survival in patients with chronic heart failure",

abstract = "Objective: Growth hormone (GH) resistance with a reduction of insulin-like growth factor-I (IGF-I) serum concentrations seems to be implicated in the catabolic process associated with chronic heart failure (CHF). However, data concerning the prognostic value of these alterations in CHF patients without cachexia are scant. In this study, we aimed to determine in CHF patients the prognostic value of IGF-I/GH ratio and its relationships with N-terminal brain natriuretic peptide (NT-proBNP), a known marker of prognosis in these patients. Design: We enrolled 82 non-cachectic patients, mean age 61 ± 13 years, with ejection fraction ",

keywords = "Chronic heart failure, GH, IGF-I, NT-proBNP, Prognosis",

author = "Mario Petretta and Annamaria Colao and Celestino Sardu and Franco Scopacasa and Paolo Marzullo and Rosario Pivonello and Luca Fontanella and {de Caterina}, Maurizio and {de Simone}, Adriano and Domenico Bonaduce",

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AU - Petretta, Mario

AU - Colao, Annamaria

AU - Sardu, Celestino

AU - Scopacasa, Franco

AU - Marzullo, Paolo

AU - Pivonello, Rosario

AU - Fontanella, Luca

AU - de Caterina, Maurizio

AU - de Simone, Adriano

AU - Bonaduce, Domenico

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AB - Objective: Growth hormone (GH) resistance with a reduction of insulin-like growth factor-I (IGF-I) serum concentrations seems to be implicated in the catabolic process associated with chronic heart failure (CHF). However, data concerning the prognostic value of these alterations in CHF patients without cachexia are scant. In this study, we aimed to determine in CHF patients the prognostic value of IGF-I/GH ratio and its relationships with N-terminal brain natriuretic peptide (NT-proBNP), a known marker of prognosis in these patients. Design: We enrolled 82 non-cachectic patients, mean age 61 ± 13 years, with ejection fraction

KW - Chronic heart failure

KW - GH

KW - IGF-I

KW - NT-proBNP

KW - Prognosis

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NT-proBNP, IGF-I and survival in patients with chronic heart failure

Abstract

Keywords

ASJC Scopus subject areas

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