Nuclear and somatic cell genetic reprogramming

Maurizio Zuccotti; Silvia Garagna; Carlo Alberto Redi

doi:10.1007/978-1-60327-905-5_4

Nuclear and somatic cell genetic reprogramming

Maurizio Zuccotti, Silvia Garagna, Carlo Alberto Redi

IRCCS Fondazione Policlinico San Matteo

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Nuclear and somatic cell genetic reprogramming has seen a huge improvement during the past 10 years since the cloning of the first mammal, Dolly the sheep. In this chapter we will summarise the advancement in nuclear and cell reprogramming by cell fusion, using amphibian eggs or egg extracts, with cell extracts, with synthetic molecules, or by induced expression of specific genes. The latter method of cell reprogramming represents a novel strategy that could allow the use of the patient's own somatic cells for cell therapy, overcoming the incompatibility of heterologous cell transplantation.

Original language	English
Title of host publication	Trends in Stem Cell Biology and Technology
Publisher	Humana Press
Pages	57-70
Number of pages	14
ISBN (Print)	9781603279048
DOIs	https://doi.org/10.1007/978-1-60327-905-5_4
Publication status	Published - 2009

Keywords

Cell extracts
Cell fusion
Cell reprogramming
iPS
Nuclear transfer

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Access to Document

10.1007/978-1-60327-905-5_4

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AB - Nuclear and somatic cell genetic reprogramming has seen a huge improvement during the past 10 years since the cloning of the first mammal, Dolly the sheep. In this chapter we will summarise the advancement in nuclear and cell reprogramming by cell fusion, using amphibian eggs or egg extracts, with cell extracts, with synthetic molecules, or by induced expression of specific genes. The latter method of cell reprogramming represents a novel strategy that could allow the use of the patient's own somatic cells for cell therapy, overcoming the incompatibility of heterologous cell transplantation.

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KW - Cell fusion

KW - Cell reprogramming

KW - iPS

KW - Nuclear transfer

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PB - Humana Press

ER -

Nuclear and somatic cell genetic reprogramming

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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