Nuclear and somatic cell genetic reprogramming

Maurizio Zuccotti, Silvia Garagna, Carlo Alberto Redi

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Nuclear and somatic cell genetic reprogramming has seen a huge improvement during the past 10 years since the cloning of the first mammal, Dolly the sheep. In this chapter we will summarise the advancement in nuclear and cell reprogramming by cell fusion, using amphibian eggs or egg extracts, with cell extracts, with synthetic molecules, or by induced expression of specific genes. The latter method of cell reprogramming represents a novel strategy that could allow the use of the patient's own somatic cells for cell therapy, overcoming the incompatibility of heterologous cell transplantation.

Original languageEnglish
Title of host publicationTrends in Stem Cell Biology and Technology
PublisherHumana Press
Pages57-70
Number of pages14
ISBN (Print)9781603279048
DOIs
Publication statusPublished - 2009

Keywords

  • Cell extracts
  • Cell fusion
  • Cell reprogramming
  • iPS
  • Nuclear transfer

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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