Nuclear bcl10 expression characterizes a group of ocular adnexa MALT lymphomas with shorter failure-free survival

Renato Franco, Francisca I. Camacho, Alessia Caleo, Stefania Staibano, Delfina Bifano, Amalia De Renzo, Fausto Tranfa, Anna De Chiara, Gerardo Botti, Roberta Merola, Ana Diez, Giulio Bonavolontà, Gaetano De Rosa, Miguel A. Piris

Research output: Contribution to journalArticle

Abstract

Ocular adnexa B-cell lymphomas are a relatively rare group of extranodal lymphomas, marginal-zone B-cell lymphomas of mucosa-associated lymphoid tissue (MALT lymphomas) being the most frequent type at this location. As with other nongastrointestinal MALT lymphomas, ocular adnexa MALT lymphomas have distinct characteristics from those of the gastric MALT model, implying specific pathogenic events, which could be of interest in the prediction of clinical behavior and the choice between therapeutic options. In a series of 39 cases of ocular adnexa MALT lymphomas, studied using a tissue microarray, we observed that the most frequent alteration was related to apoptosis regulation. Thus, caspase 3 activity was completely abolished, and phosphorylated IκBα, a marker of NF-κB activation, showed increased expression, while cases with an increased number of large cells displayed increased expression of survivin and other cell-cycle-related proteins, such as cyclin A, cyclin E and Ki67, and p16 expression was reduced. There were no occurrences of t(11;18)(q21,q21), while 5/37 cases exhibited t(14;18)(q32;q21). Aberrant nuclear expression of bcl10 was observed in 11 cases, independently of the presence of translocations, and was significantly associated with phosphorylated IκBα expression and a reduced TdT-mediated biotin-dUTP nicked-end labeling apoptotic index. Moreover, patients with tumoral bcl10 nuclear expression showed shorter failure-free survival.

Original languageEnglish
Pages (from-to)1055-1067
Number of pages13
JournalModern Pathology
Volume19
Issue number8
DOIs
Publication statusPublished - Aug 12 2006

Fingerprint

Marginal Zone B-Cell Lymphoma
Survival
Choice Behavior
Cyclin A
Cyclin E
Cell Cycle Proteins
B-Cell Lymphoma
Biotin
Caspase 3
Lymphoma
Stomach
Cell Count
Apoptosis

Keywords

  • bcl10
  • Ocular adnexa MALT lymphomas
  • t(11;18)(q21;q21)
  • t(14;18)(q21;q32)

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Franco, R., Camacho, F. I., Caleo, A., Staibano, S., Bifano, D., De Renzo, A., ... Piris, M. A. (2006). Nuclear bcl10 expression characterizes a group of ocular adnexa MALT lymphomas with shorter failure-free survival. Modern Pathology, 19(8), 1055-1067. https://doi.org/10.1038/modpathol.3800597

Nuclear bcl10 expression characterizes a group of ocular adnexa MALT lymphomas with shorter failure-free survival. / Franco, Renato; Camacho, Francisca I.; Caleo, Alessia; Staibano, Stefania; Bifano, Delfina; De Renzo, Amalia; Tranfa, Fausto; De Chiara, Anna; Botti, Gerardo; Merola, Roberta; Diez, Ana; Bonavolontà, Giulio; De Rosa, Gaetano; Piris, Miguel A.

In: Modern Pathology, Vol. 19, No. 8, 12.08.2006, p. 1055-1067.

Research output: Contribution to journalArticle

Franco, R, Camacho, FI, Caleo, A, Staibano, S, Bifano, D, De Renzo, A, Tranfa, F, De Chiara, A, Botti, G, Merola, R, Diez, A, Bonavolontà, G, De Rosa, G & Piris, MA 2006, 'Nuclear bcl10 expression characterizes a group of ocular adnexa MALT lymphomas with shorter failure-free survival', Modern Pathology, vol. 19, no. 8, pp. 1055-1067. https://doi.org/10.1038/modpathol.3800597
Franco, Renato ; Camacho, Francisca I. ; Caleo, Alessia ; Staibano, Stefania ; Bifano, Delfina ; De Renzo, Amalia ; Tranfa, Fausto ; De Chiara, Anna ; Botti, Gerardo ; Merola, Roberta ; Diez, Ana ; Bonavolontà, Giulio ; De Rosa, Gaetano ; Piris, Miguel A. / Nuclear bcl10 expression characterizes a group of ocular adnexa MALT lymphomas with shorter failure-free survival. In: Modern Pathology. 2006 ; Vol. 19, No. 8. pp. 1055-1067.
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abstract = "Ocular adnexa B-cell lymphomas are a relatively rare group of extranodal lymphomas, marginal-zone B-cell lymphomas of mucosa-associated lymphoid tissue (MALT lymphomas) being the most frequent type at this location. As with other nongastrointestinal MALT lymphomas, ocular adnexa MALT lymphomas have distinct characteristics from those of the gastric MALT model, implying specific pathogenic events, which could be of interest in the prediction of clinical behavior and the choice between therapeutic options. In a series of 39 cases of ocular adnexa MALT lymphomas, studied using a tissue microarray, we observed that the most frequent alteration was related to apoptosis regulation. Thus, caspase 3 activity was completely abolished, and phosphorylated IκBα, a marker of NF-κB activation, showed increased expression, while cases with an increased number of large cells displayed increased expression of survivin and other cell-cycle-related proteins, such as cyclin A, cyclin E and Ki67, and p16 expression was reduced. There were no occurrences of t(11;18)(q21,q21), while 5/37 cases exhibited t(14;18)(q32;q21). Aberrant nuclear expression of bcl10 was observed in 11 cases, independently of the presence of translocations, and was significantly associated with phosphorylated IκBα expression and a reduced TdT-mediated biotin-dUTP nicked-end labeling apoptotic index. Moreover, patients with tumoral bcl10 nuclear expression showed shorter failure-free survival.",
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AU - Tranfa, Fausto

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AU - Botti, Gerardo

AU - Merola, Roberta

AU - Diez, Ana

AU - Bonavolontà, Giulio

AU - De Rosa, Gaetano

AU - Piris, Miguel A.

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N2 - Ocular adnexa B-cell lymphomas are a relatively rare group of extranodal lymphomas, marginal-zone B-cell lymphomas of mucosa-associated lymphoid tissue (MALT lymphomas) being the most frequent type at this location. As with other nongastrointestinal MALT lymphomas, ocular adnexa MALT lymphomas have distinct characteristics from those of the gastric MALT model, implying specific pathogenic events, which could be of interest in the prediction of clinical behavior and the choice between therapeutic options. In a series of 39 cases of ocular adnexa MALT lymphomas, studied using a tissue microarray, we observed that the most frequent alteration was related to apoptosis regulation. Thus, caspase 3 activity was completely abolished, and phosphorylated IκBα, a marker of NF-κB activation, showed increased expression, while cases with an increased number of large cells displayed increased expression of survivin and other cell-cycle-related proteins, such as cyclin A, cyclin E and Ki67, and p16 expression was reduced. There were no occurrences of t(11;18)(q21,q21), while 5/37 cases exhibited t(14;18)(q32;q21). Aberrant nuclear expression of bcl10 was observed in 11 cases, independently of the presence of translocations, and was significantly associated with phosphorylated IκBα expression and a reduced TdT-mediated biotin-dUTP nicked-end labeling apoptotic index. Moreover, patients with tumoral bcl10 nuclear expression showed shorter failure-free survival.

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