Nuclear bile acid receptor FXR as pharmacological target: Are we there yet?

Salvatore Modica, Antonio Moschetta

Research output: Contribution to journalArticle


The farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily that is primarily expressed in the enterohepatic system where it functions as intracellular sensor for bile acids. Ligand dependent FXR activation induces transcriptional responses to coordinately regulate bile acid, cholesterol, triglyceride and glucose metabolism, and to protect the intestinal mucosa from bacterial overgrowth and inflammatory insults. Here we discuss the latest discoveries in FXR-driven metabolic pathways with relevance to pathophysiology and novel therapeutic approaches of several conditions such as hypertriglyceridemia, type 2 diabetes, cholesterol gallstone disease, steato-hepatitis and metabolic syndrome.

Original languageEnglish
Pages (from-to)5492-5499
Number of pages8
JournalFEBS Letters
Issue number23
Publication statusPublished - Oct 9 2006


  • Cholesterol
  • Farnesoid X receptor
  • Gallstones
  • Hypertriglyceridemia
  • Metabolic syndrome

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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