Nuclear diacylglycerol kinases: emerging downstream regulators in cell signaling networks.

C. Evangelisti, R. Bortul, F. Falà, G. Tabellini, K. Goto, A. M. Martelli

Research output: Contribution to journalArticle

Abstract

There exists an active lipid metabolism in the nucleus, which is regulated differentially from the lipid metabolism taking place elsewhere in the cell. Evidence has been accumulated that nuclear lipid metabolism is closely involved in a variety of cell responses, including proliferation, differentiation, and apoptosis. A fundamental lipid second messenger which is generated in the nucleus is diacylglycerol, that is mainly known for its role as an activator of some protein kinase C isoforms. Diacylglycerol kinases attenuate diacylglycerol signaling by converting this lipid to phosphatidic acid, which also has signaling functions. Ten mammalian diacylglycerol kinase isoforms have been cloned so far, and some of them are found also in the nucleus, either as resident proteins or after migration from cytoplasm in response to various agonists. Experiments using cultured cells have demonstrated that nuclear diacylglycerol kinases have prominent roles in cell cycle regulation and differentiation. In this review, the emerging roles played by diacylglycerol kinases in the nucleus, such as the control of G1/S phase transition, are discussed.

Original languageEnglish
Pages (from-to)573-579
Number of pages7
JournalHistology and Histopathology
Volume22
Issue number5
Publication statusPublished - May 2007

Fingerprint

Diacylglycerol Kinase
Lipid Metabolism
Diglycerides
Protein Isoforms
Lipids
Phosphatidic Acids
Phase Transition
G1 Phase
Second Messenger Systems
S Phase
Protein Kinase C
Cell Differentiation
Cultured Cells
Cell Cycle
Cytoplasm
Apoptosis
Proteins

ASJC Scopus subject areas

  • Cell Biology
  • Anatomy
  • Histology
  • Pathology and Forensic Medicine

Cite this

Evangelisti, C., Bortul, R., Falà, F., Tabellini, G., Goto, K., & Martelli, A. M. (2007). Nuclear diacylglycerol kinases: emerging downstream regulators in cell signaling networks. Histology and Histopathology, 22(5), 573-579.

Nuclear diacylglycerol kinases : emerging downstream regulators in cell signaling networks. / Evangelisti, C.; Bortul, R.; Falà, F.; Tabellini, G.; Goto, K.; Martelli, A. M.

In: Histology and Histopathology, Vol. 22, No. 5, 05.2007, p. 573-579.

Research output: Contribution to journalArticle

Evangelisti, C, Bortul, R, Falà, F, Tabellini, G, Goto, K & Martelli, AM 2007, 'Nuclear diacylglycerol kinases: emerging downstream regulators in cell signaling networks.', Histology and Histopathology, vol. 22, no. 5, pp. 573-579.
Evangelisti C, Bortul R, Falà F, Tabellini G, Goto K, Martelli AM. Nuclear diacylglycerol kinases: emerging downstream regulators in cell signaling networks. Histology and Histopathology. 2007 May;22(5):573-579.
Evangelisti, C. ; Bortul, R. ; Falà, F. ; Tabellini, G. ; Goto, K. ; Martelli, A. M. / Nuclear diacylglycerol kinases : emerging downstream regulators in cell signaling networks. In: Histology and Histopathology. 2007 ; Vol. 22, No. 5. pp. 573-579.
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