Nuclear diacylglycerol kinases: Emerging downstream regulators in cell signaling networks

C. Evangelisti, R. Bortul, F. Falà, G. Tabellini, K. Goto, Alberto M. Martelli

Research output: Contribution to journalArticlepeer-review


There exists an active lipid metabolism in the nucleus, which is regulated differentially from the lipid metabolism taking place elsewhere in the cell. Evidence has been accumulated that nuclear lipid metabolism is closely involved in a variety of cell responses, including proliferation, differentiation, and apoptosis. A fundamental lipid second messenger which is generated in the nucleus is diacylglycerol, that is mainly known for its role as an activator of some protein kinase C isoforms. Diacylglycerol kinases attenuate diacylglycerol signaling by converting this lipid to phosphatidic acid, which also has signaling functions. Ten mammalian diacylglycerol kinase isoforms have been cloned so far, and some of them are found also in the nucleus, either as resident proteins or after migration from cytoplasm in response to various agonists. Experiments using cultured cells have demonstrated that nuclear diacylglycerol kinases have prominent roles in cell cycle regulation and differentiation. In this review, the emerging roles played by diacylglycerol kinases in the nucleus, such as the control of G1/S phase transition, are discussed.

Original languageEnglish
Pages (from-to)573-579
Number of pages7
JournalHistology and Histopathology
Issue number4-6
Publication statusPublished - Apr 2007


  • Diacylglycerol
  • Differentiation
  • Nuclear matrix
  • Nucleus
  • Proliferation

ASJC Scopus subject areas

  • Cell Biology
  • Anatomy
  • Histology
  • Pathology and Forensic Medicine


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