Nuclear DNA as Predictor of Acute Kidney Injury in Patients Undergoing Coronary Artery Bypass Graft: A Pilot Study

VV Likhvantsev, G Landoni, OA Grebenchikov, YV Skripkin, TS Zabelina, LA Zinovkina, AS Prikhodko, VV Lomivorotov, RA Zinovkin

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: To measure the release of plasma nuclear deoxyribonucleic acid (DNA) and to assess the relationship between nuclear DNA level and acute kidney injury occurrence in patients undergoing cardiac surgery. Setting: Cardiovascular anesthesiology and intensive care unit of a large tertiary-care university hospital. Design: Prospective observational study. Participants: Fifty adult patients undergoing cardiac surgery. Interventions: Nuclear DNA concentration was measured in the plasma. The relationship between the level of nuclear DNA and the incidence of acute kidney injury after coronary artery bypass grafting was investigated. Measurements and Main Results: Cardiac surgery leads to significant increase in plasma nuclear DNA with peak levels 12 hours after surgery (median [interquartile range] 7.0 [9.6-22.5] μg/mL). No difference was observed between off-pump and on-pump surgical techniques. Nuclear DNA was the only predictor of acute kidney injury between baseline and early postoperative risk factors. Conclusions: The authors found an increase of nuclear DNA in the plasma of patients who had undergone coronary artery bypass grafting, with a peak after 12 hours and an association of nuclear DNA with postoperative acute kidney injury. © 2017 Elsevier Inc.
Original languageEnglish
Pages (from-to)2080-2085
Number of pages6
JournalJournal of Cardiothoracic and Vascular Anesthesia
Volume31
Issue number6
DOIs
Publication statusPublished - 2017

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Acute Kidney Injury
Coronary Artery Bypass
Transplants
DNA
Thoracic Surgery
Anesthesiology
Tertiary Healthcare
Observational Studies
Intensive Care Units
Prospective Studies
Incidence

Cite this

Nuclear DNA as Predictor of Acute Kidney Injury in Patients Undergoing Coronary Artery Bypass Graft: A Pilot Study. / Likhvantsev, VV; Landoni, G; Grebenchikov, OA; Skripkin, YV; Zabelina, TS; Zinovkina, LA; Prikhodko, AS; Lomivorotov, VV; Zinovkin, RA.

In: Journal of Cardiothoracic and Vascular Anesthesia, Vol. 31, No. 6, 2017, p. 2080-2085.

Research output: Contribution to journalArticle

Likhvantsev, VV, Landoni, G, Grebenchikov, OA, Skripkin, YV, Zabelina, TS, Zinovkina, LA, Prikhodko, AS, Lomivorotov, VV & Zinovkin, RA 2017, 'Nuclear DNA as Predictor of Acute Kidney Injury in Patients Undergoing Coronary Artery Bypass Graft: A Pilot Study', Journal of Cardiothoracic and Vascular Anesthesia, vol. 31, no. 6, pp. 2080-2085. https://doi.org/10.1053/j.jvca.2017.04.051
Likhvantsev, VV ; Landoni, G ; Grebenchikov, OA ; Skripkin, YV ; Zabelina, TS ; Zinovkina, LA ; Prikhodko, AS ; Lomivorotov, VV ; Zinovkin, RA. / Nuclear DNA as Predictor of Acute Kidney Injury in Patients Undergoing Coronary Artery Bypass Graft: A Pilot Study. In: Journal of Cardiothoracic and Vascular Anesthesia. 2017 ; Vol. 31, No. 6. pp. 2080-2085.
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abstract = "Objective: To measure the release of plasma nuclear deoxyribonucleic acid (DNA) and to assess the relationship between nuclear DNA level and acute kidney injury occurrence in patients undergoing cardiac surgery. Setting: Cardiovascular anesthesiology and intensive care unit of a large tertiary-care university hospital. Design: Prospective observational study. Participants: Fifty adult patients undergoing cardiac surgery. Interventions: Nuclear DNA concentration was measured in the plasma. The relationship between the level of nuclear DNA and the incidence of acute kidney injury after coronary artery bypass grafting was investigated. Measurements and Main Results: Cardiac surgery leads to significant increase in plasma nuclear DNA with peak levels 12 hours after surgery (median [interquartile range] 7.0 [9.6-22.5] μg/mL). No difference was observed between off-pump and on-pump surgical techniques. Nuclear DNA was the only predictor of acute kidney injury between baseline and early postoperative risk factors. Conclusions: The authors found an increase of nuclear DNA in the plasma of patients who had undergone coronary artery bypass grafting, with a peak after 12 hours and an association of nuclear DNA with postoperative acute kidney injury. {\circledC} 2017 Elsevier Inc.",
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AU - Likhvantsev, VV

AU - Landoni, G

AU - Grebenchikov, OA

AU - Skripkin, YV

AU - Zabelina, TS

AU - Zinovkina, LA

AU - Prikhodko, AS

AU - Lomivorotov, VV

AU - Zinovkin, RA

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N2 - Objective: To measure the release of plasma nuclear deoxyribonucleic acid (DNA) and to assess the relationship between nuclear DNA level and acute kidney injury occurrence in patients undergoing cardiac surgery. Setting: Cardiovascular anesthesiology and intensive care unit of a large tertiary-care university hospital. Design: Prospective observational study. Participants: Fifty adult patients undergoing cardiac surgery. Interventions: Nuclear DNA concentration was measured in the plasma. The relationship between the level of nuclear DNA and the incidence of acute kidney injury after coronary artery bypass grafting was investigated. Measurements and Main Results: Cardiac surgery leads to significant increase in plasma nuclear DNA with peak levels 12 hours after surgery (median [interquartile range] 7.0 [9.6-22.5] μg/mL). No difference was observed between off-pump and on-pump surgical techniques. Nuclear DNA was the only predictor of acute kidney injury between baseline and early postoperative risk factors. Conclusions: The authors found an increase of nuclear DNA in the plasma of patients who had undergone coronary artery bypass grafting, with a peak after 12 hours and an association of nuclear DNA with postoperative acute kidney injury. © 2017 Elsevier Inc.

AB - Objective: To measure the release of plasma nuclear deoxyribonucleic acid (DNA) and to assess the relationship between nuclear DNA level and acute kidney injury occurrence in patients undergoing cardiac surgery. Setting: Cardiovascular anesthesiology and intensive care unit of a large tertiary-care university hospital. Design: Prospective observational study. Participants: Fifty adult patients undergoing cardiac surgery. Interventions: Nuclear DNA concentration was measured in the plasma. The relationship between the level of nuclear DNA and the incidence of acute kidney injury after coronary artery bypass grafting was investigated. Measurements and Main Results: Cardiac surgery leads to significant increase in plasma nuclear DNA with peak levels 12 hours after surgery (median [interquartile range] 7.0 [9.6-22.5] μg/mL). No difference was observed between off-pump and on-pump surgical techniques. Nuclear DNA was the only predictor of acute kidney injury between baseline and early postoperative risk factors. Conclusions: The authors found an increase of nuclear DNA in the plasma of patients who had undergone coronary artery bypass grafting, with a peak after 12 hours and an association of nuclear DNA with postoperative acute kidney injury. © 2017 Elsevier Inc.

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