Nuclear envelope protein autoantibodies/antilamin autoantibodies

Pietro Invernizzi, J. ózefa Wesierska-Gadek

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Aroundthe mid-1980s, a number of nuclear envelope structures have been recognized as specific targets of antinuclear autoantibodies (ANA) producing a rim-like staining (anti-NE) at indirect immunofluorescence. In particular, peripheral pattern results from autoantibodies directed against proteins within three components of the nuclear envelope: the nuclear lamina (lamins A, B, and C), the nuclear pore complex (gp210, p62, and Tpr), and the inner nuclear membrane (LAP1, LAP2, and LBR). Although the fluorescent ANA test using HEp-2 cells is still the most widely used screening assay for anti-NE testing, new accurate immunochemical tests based on enzyme-linked immunosorbent (ELISA) and immunoblotting with purified antigens have been developed. Anti-NE is generally believed to be non-pathogenic but represent specific disease markers and is useful diagnostic tools. Immunoreactivities against components of the nuclear pore complex have been shown to be associated with primary biliary cirrhosis (PBC), whereas autoantibodies to the lamins are associated with various autoimmune diseases, such as autoimmune hepatitis, systemic lupus erythematosus, and antiphospholipid antibodies. In the last few years, data from different groups indicated that PBC-specific anti-NE correlate with disease severity and may, therefore, be a marker of poor prognosis. Much less is known, however, regarding the clinical and prognostic role of anti-NE in other autoimmune conditions.

Original languageEnglish
Title of host publicationAutoantibodies
PublisherElsevier Inc.
Pages191-196
Number of pages6
ISBN (Print)9780444527639
DOIs
Publication statusPublished - 2007

Fingerprint

Nuclear Envelope
Nuclear Proteins
Autoantibodies
Nuclear Pore
Biliary Liver Cirrhosis
Proteins
Lamin Type B
Nuclear Lamina
Lamins
Lamin Type A
Autoimmune Hepatitis
Immunosorbents
Antiphospholipid Antibodies
Indirect Fluorescent Antibody Technique
Immunoblotting
Systemic Lupus Erythematosus
Autoimmune Diseases
Assays
Screening
Enzyme-Linked Immunosorbent Assay

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Invernizzi, P., & ózefa Wesierska-Gadek, J. (2007). Nuclear envelope protein autoantibodies/antilamin autoantibodies. In Autoantibodies (pp. 191-196). Elsevier Inc.. https://doi.org/10.1016/B978-044452763-9/50029-9

Nuclear envelope protein autoantibodies/antilamin autoantibodies. / Invernizzi, Pietro; ózefa Wesierska-Gadek, J.

Autoantibodies. Elsevier Inc., 2007. p. 191-196.

Research output: Chapter in Book/Report/Conference proceedingChapter

Invernizzi, P & ózefa Wesierska-Gadek, J 2007, Nuclear envelope protein autoantibodies/antilamin autoantibodies. in Autoantibodies. Elsevier Inc., pp. 191-196. https://doi.org/10.1016/B978-044452763-9/50029-9
Invernizzi P, ózefa Wesierska-Gadek J. Nuclear envelope protein autoantibodies/antilamin autoantibodies. In Autoantibodies. Elsevier Inc. 2007. p. 191-196 https://doi.org/10.1016/B978-044452763-9/50029-9
Invernizzi, Pietro ; ózefa Wesierska-Gadek, J. / Nuclear envelope protein autoantibodies/antilamin autoantibodies. Autoantibodies. Elsevier Inc., 2007. pp. 191-196
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