Nuclear functions of the tyrosine kinase Src: International Journal of Molecular Sciences

G. Bagnato, M. Leopizzi, E. Urciuoli, B. Peruzzi

Research output: Contribution to journalArticlepeer-review

Abstract

Src is the representative member of the Src-family kinases (SFKs), a group of tyrosine kinases involved in several cellular processes. Its main function has been for long confined to the plasma membrane/cytoplasm compartment, being a myristoylated protein anchored to the cell membrane and functioning downstream to receptors, most of them lacking intrinsic kinase activity. In the last decades, new roles for some SFKs have been described in the nuclear compartment, suggesting that these proteins can also be involved in directly regulating gene transcription or nucleoskeleton architecture. In this review, we focused on those nuclear functions specifically attributable to Src, by considering its function as both tyrosine kinase and adapting molecule. In particular, we addressed the Src involvement in physiological as well as in pathological conditions, especially in tumors. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Original languageEnglish
JournalInt. J. Mol. Sci.
Volume21
Issue number8
DOIs
Publication statusPublished - 2020

Keywords

  • Nucleus
  • Oncogenes
  • Src-family kinases
  • Subcellular localization
  • Tyrosine phosphorylation
  • emerin
  • estrogen receptor
  • histone acetlytransferase
  • histone deacetylase
  • peptides and proteins
  • protein SH3
  • protein tyrosine kinase
  • protein tyrosine phosphatase SHP 2
  • scatter factor receptor
  • src family kinase
  • STAT protein
  • stress activated protein kinase
  • tafazzin
  • transcription factor RUNX3
  • unclassified drug
  • yes associated protein
  • protein binding
  • tyrosine
  • amino acid sequence
  • angiogenesis
  • cancer prognosis
  • cellular distribution
  • chromatin
  • cytoskeleton
  • DNA damage
  • gene expression
  • genetic transcription
  • hippo signaling
  • human
  • mechanotransduction
  • metastasis
  • nonhuman
  • nuclear localization signal
  • nucleocytoplasmic transport
  • pathophysiology
  • protein function
  • protein interaction
  • protein localization
  • protein phosphorylation
  • Review
  • animal
  • cell nucleus
  • chemistry
  • genetics
  • intracellular space
  • metabolism
  • phosphorylation
  • protein domain
  • protein transport
  • Animals
  • Cell Nucleus
  • Humans
  • Intracellular Space
  • Phosphorylation
  • Protein Binding
  • Protein Interaction Domains and Motifs
  • Protein Transport
  • src-Family Kinases
  • Tyrosine

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