Nuclear grade and DNA ploidy in stage IV breast cancer with only visceral metastases at initial diagnosis

Mario De Lena, Anna Barletta, Francesco Marzullo, Mario Rabinovich, Bernardo Leone, Carlos Vallejo, Mario Machiavelli, Alberto Romero, Juan Perez, Juan Lacava, Maria Andrea Cuevas, Ricardo Rodriguez, Francesco Schittulli, Angelo Paradiso

Research output: Contribution to journalArticle

Abstract

Aims and background: The presence of early metastases to distant sites in breast cancer patients is an infrequent event whose mechanisms are still not clear. The aim of this study was to evaluate the biologic and clinical role of DNA ploidy and cell nuclear grade of primary tumors in the metastatic process of a series of stage IV previously untreated breast cancer patients with only visceral metastases. Methods: DNA flow cytometry analysis on paraffin-embedded material and cell nuclear grading of primary tumors was performed on a series of 50 breast cancer patients with only visceral metastases at the time of initial diagnosis. Results: Aneuploidy was found in 28/46 (61%) of evaluable cases and was independent of site of involvement, clinical response, time to progression and overall survival of patients. Of the 46 cases evaluable for nuclear grade, 5 (11%), 16 (35%) and 25 (54%) were classified as G1 (well-differentiated) G2 and G3, respectively. Nuclear grade also was unrelated to response to therapy and overall survival, whereas time to progression was significantly longer in G1-2 than G3 tumors with the logrank test (P <0.03) and multivariate analysis. Conclusions: Our results seem to stress the difficulty to individualize different prognostic subsets from a series of breast cancer patients with only visceral metastases at initial diagnosis according to DNA flow cytometry and nuclear grade.

Original languageEnglish
Pages (from-to)386-389
Number of pages4
JournalTumori
Volume82
Issue number4
Publication statusPublished - Jul 1996

Keywords

  • breast cancer
  • nuclear grade
  • ploidy
  • visceral metastases

ASJC Scopus subject areas

  • Cancer Research

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  • Cite this

    De Lena, M., Barletta, A., Marzullo, F., Rabinovich, M., Leone, B., Vallejo, C., Machiavelli, M., Romero, A., Perez, J., Lacava, J., Cuevas, M. A., Rodriguez, R., Schittulli, F., & Paradiso, A. (1996). Nuclear grade and DNA ploidy in stage IV breast cancer with only visceral metastases at initial diagnosis. Tumori, 82(4), 386-389.