Abstract
A distinct polyphosphoinositide cycle is present in the nucleus, and growing evidence suggests its importance in DNA replication, gene transcript ion, and apoptosis. Even though it was initially thought that nuclear inositol lipids would function as a source for second messengers, recent findings strongly indicate that lipids present in the nucleus also fulfil other roles. The scope of this review is to high light the most intriguing advances made in the field over the last few years, such as the possibility that nuclear phosphatidylinositol (4,5) bisphosphate is involved in maintaining chromatin in a transcriptionalIy active conformation, the new emerging roles for intranuclear phosphatidyl inositol (3,4,5) trisphosphate and phosphoinositide 3-kinase, and the evidence which suggests a tight relationship between a decreased level of nuclear phosphoinositide specific phospholipase C-β1 and the evolution of myelodisplastic syndrome into acute myeloid leukemia.
| Original language | English |
|---|---|
| Pages (from-to) | 285-292 |
| Number of pages | 8 |
| Journal | Journal of Cellular Biochemistry |
| Volume | 96 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Oct 1 2005 |
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Keywords
- Apoptosis
- Chromatin organization
- Myelodisplastic syndrome
- Nucleus
- Phosphoinositide 3-kinase
- Phospholipase C
- Ptdlns(4,5)P
ASJC Scopus subject areas
- Biochemistry
- Cell Biology
Cite this
Nuclear inositol lipid metabolism : More than just second messenger generation? / Martelli, Alberto M.; Follo, Matilde Yung; Evangelisti, Camilla; Falà, Federica; Fiume, Roberta; Billi, Anna Maria; Cocco, Lucio.
In: Journal of Cellular Biochemistry, Vol. 96, No. 2, 01.10.2005, p. 285-292.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Nuclear inositol lipid metabolism
T2 - More than just second messenger generation?
AU - Martelli, Alberto M.
AU - Follo, Matilde Yung
AU - Evangelisti, Camilla
AU - Falà, Federica
AU - Fiume, Roberta
AU - Billi, Anna Maria
AU - Cocco, Lucio
PY - 2005/10/1
Y1 - 2005/10/1
N2 - A distinct polyphosphoinositide cycle is present in the nucleus, and growing evidence suggests its importance in DNA replication, gene transcript ion, and apoptosis. Even though it was initially thought that nuclear inositol lipids would function as a source for second messengers, recent findings strongly indicate that lipids present in the nucleus also fulfil other roles. The scope of this review is to high light the most intriguing advances made in the field over the last few years, such as the possibility that nuclear phosphatidylinositol (4,5) bisphosphate is involved in maintaining chromatin in a transcriptionalIy active conformation, the new emerging roles for intranuclear phosphatidyl inositol (3,4,5) trisphosphate and phosphoinositide 3-kinase, and the evidence which suggests a tight relationship between a decreased level of nuclear phosphoinositide specific phospholipase C-β1 and the evolution of myelodisplastic syndrome into acute myeloid leukemia.
AB - A distinct polyphosphoinositide cycle is present in the nucleus, and growing evidence suggests its importance in DNA replication, gene transcript ion, and apoptosis. Even though it was initially thought that nuclear inositol lipids would function as a source for second messengers, recent findings strongly indicate that lipids present in the nucleus also fulfil other roles. The scope of this review is to high light the most intriguing advances made in the field over the last few years, such as the possibility that nuclear phosphatidylinositol (4,5) bisphosphate is involved in maintaining chromatin in a transcriptionalIy active conformation, the new emerging roles for intranuclear phosphatidyl inositol (3,4,5) trisphosphate and phosphoinositide 3-kinase, and the evidence which suggests a tight relationship between a decreased level of nuclear phosphoinositide specific phospholipase C-β1 and the evolution of myelodisplastic syndrome into acute myeloid leukemia.
KW - Apoptosis
KW - Chromatin organization
KW - Myelodisplastic syndrome
KW - Nucleus
KW - Phosphoinositide 3-kinase
KW - Phospholipase C
KW - Ptdlns(4,5)P
UR - http://www.scopus.com/inward/record.url?scp=26444458961&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=26444458961&partnerID=8YFLogxK
U2 - 10.1002/jcb.20527
DO - 10.1002/jcb.20527
M3 - Article
C2 - 16088939
AN - SCOPUS:26444458961
VL - 96
SP - 285
EP - 292
JO - Journal of Cellular Biochemistry
JF - Journal of Cellular Biochemistry
SN - 0730-2312
IS - 2
ER -