Nuclear localization of phosphorylated c-Myc protein in human tumor cells

C. Soldani, M. G. Bottone, M. Biggiogera, C. Alpini, A. I. Scovassi, T. Martin, C. Pellicciari

Research output: Contribution to journalArticlepeer-review

Abstract

Using immunocytochemical techniques at light and electron microscopy, we analysed the distribution of phosphorylated c-Myc in actively proliferating human HeLa cells. The distribution pattern of c-Myc was also compared with those of other ribonucleoprotein (RNP)-containing components (PANA, hnRNP-core proteins, fibrillarin) or RNP-associated nuclear proteins (SC-35 splicing factor). Our results provide the first evidence that phosphorylated c-Myc accumulates in the nucleus of tumor cells, where it colocalizes with fibrillarin, both in the nucleolus and in extranucleolar structures.

Original languageEnglish
Pages (from-to)377-380
Number of pages4
JournalEuropean journal of histochemistry : EJH
Volume46
Issue number4
Publication statusPublished - 2002

Keywords

  • C-Myc
  • Fibrillarin
  • Fluorescence microscopy
  • Immunocytochemistry
  • Nuclear bodies
  • Nucleolus

ASJC Scopus subject areas

  • Cell Biology
  • Anatomy
  • Animal Science and Zoology
  • Developmental Biology

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