Metodiche medico-nucleari per la diagnosi dei tumori surrenalici.

Translated title of the contribution: Nuclear medicine methods for the diagnosis of adrenal tumors

M. Gregianin, F. Bui, L. Varotto, P. Zucchetta, C. Macri

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Adrenal scintigraphy using 131I-6-beta-iodomethyl-19-norcholesterol or 6-methyl-75Se-methyl-19-norcholesterol is a function-dependent imaging method which, in association with high-resolution spatial imaging techniques, plays an essential role in the study of adrenocortical hyperfunction. It can distinguish between bilateral cortical hyperplasia and monolateral adenoma or carcinoma and can lateralise the adenoma. In patients with Cushing syndrome, in addition to allowing a distinction to be made between ACTH-dependent forms and independent forms, adrenocortical scintigraphy is particularly appropriate to identify non-common forms of adenomatous hyperplasia. Adrenocortical scintigraphy, performed during dexamethasone administration, is an accurate mean of differentiating bilateral adrenal hyperplasia from monolateral forms (adenoma or carcinoma) in patients with Conn's syndrome. Owing to the gradual spread of high-resolution spatial imaging techniques, the problem of the diagnostic classification of so-called "incidentalomas" (clinically silent masses discovered by chance) is a subject of considerable interest. Adreno-cortical scintigraphy appears to be able to provide an important contribution to identifying the functional behaviour of these tumours. Since the early 80s meta-iodobenzyl-guanidine (MIBG), marked with 131I or 123I, with a structure similar to norepinephrine and characterized by selective tropism for sympathetic and chromaffin tissue, has been used for the scintigraphic study of adrenal medulla. MIBG scintigraphy has been found to be particularly appropriate for the study of intra- and extra-adrenal, single and multiple, benign and malignant pheochromocytomas. This method has a high overall sensitivity and specificity. Lastly, MIBG scintigraphy is useful in the study of neuroblastoma.

Original languageItalian
Pages (from-to)27-38
Number of pages12
JournalMinerva Endocrinologica
Volume20
Issue number1
Publication statusPublished - Mar 1995

Fingerprint

Glandular and Epithelial Neoplasms
Nuclear Medicine
Radionuclide Imaging
Guanidine
Adenoma
Hyperplasia
Adrenocortical Hyperfunction
Carcinoma
Hyperaldosteronism
Adrenal Medulla
Tropism
Cushing Syndrome
Pheochromocytoma
Neuroblastoma
Adrenocorticotropic Hormone
Dexamethasone
Norepinephrine
Sensitivity and Specificity
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Gregianin, M., Bui, F., Varotto, L., Zucchetta, P., & Macri, C. (1995). Metodiche medico-nucleari per la diagnosi dei tumori surrenalici. Minerva Endocrinologica, 20(1), 27-38.

Metodiche medico-nucleari per la diagnosi dei tumori surrenalici. / Gregianin, M.; Bui, F.; Varotto, L.; Zucchetta, P.; Macri, C.

In: Minerva Endocrinologica, Vol. 20, No. 1, 03.1995, p. 27-38.

Research output: Contribution to journalArticle

Gregianin, M, Bui, F, Varotto, L, Zucchetta, P & Macri, C 1995, 'Metodiche medico-nucleari per la diagnosi dei tumori surrenalici.', Minerva Endocrinologica, vol. 20, no. 1, pp. 27-38.
Gregianin M, Bui F, Varotto L, Zucchetta P, Macri C. Metodiche medico-nucleari per la diagnosi dei tumori surrenalici. Minerva Endocrinologica. 1995 Mar;20(1):27-38.
Gregianin, M. ; Bui, F. ; Varotto, L. ; Zucchetta, P. ; Macri, C. / Metodiche medico-nucleari per la diagnosi dei tumori surrenalici. In: Minerva Endocrinologica. 1995 ; Vol. 20, No. 1. pp. 27-38.
@article{88cf791215994f239eefd5674e51096c,
title = "Metodiche medico-nucleari per la diagnosi dei tumori surrenalici.",
abstract = "Adrenal scintigraphy using 131I-6-beta-iodomethyl-19-norcholesterol or 6-methyl-75Se-methyl-19-norcholesterol is a function-dependent imaging method which, in association with high-resolution spatial imaging techniques, plays an essential role in the study of adrenocortical hyperfunction. It can distinguish between bilateral cortical hyperplasia and monolateral adenoma or carcinoma and can lateralise the adenoma. In patients with Cushing syndrome, in addition to allowing a distinction to be made between ACTH-dependent forms and independent forms, adrenocortical scintigraphy is particularly appropriate to identify non-common forms of adenomatous hyperplasia. Adrenocortical scintigraphy, performed during dexamethasone administration, is an accurate mean of differentiating bilateral adrenal hyperplasia from monolateral forms (adenoma or carcinoma) in patients with Conn's syndrome. Owing to the gradual spread of high-resolution spatial imaging techniques, the problem of the diagnostic classification of so-called {"}incidentalomas{"} (clinically silent masses discovered by chance) is a subject of considerable interest. Adreno-cortical scintigraphy appears to be able to provide an important contribution to identifying the functional behaviour of these tumours. Since the early 80s meta-iodobenzyl-guanidine (MIBG), marked with 131I or 123I, with a structure similar to norepinephrine and characterized by selective tropism for sympathetic and chromaffin tissue, has been used for the scintigraphic study of adrenal medulla. MIBG scintigraphy has been found to be particularly appropriate for the study of intra- and extra-adrenal, single and multiple, benign and malignant pheochromocytomas. This method has a high overall sensitivity and specificity. Lastly, MIBG scintigraphy is useful in the study of neuroblastoma.",
author = "M. Gregianin and F. Bui and L. Varotto and P. Zucchetta and C. Macri",
year = "1995",
month = "3",
language = "Italian",
volume = "20",
pages = "27--38",
journal = "Minerva Endocrinologica",
issn = "0391-1977",
publisher = "Edizioni Minerva Medica S.p.A.",
number = "1",

}

TY - JOUR

T1 - Metodiche medico-nucleari per la diagnosi dei tumori surrenalici.

AU - Gregianin, M.

AU - Bui, F.

AU - Varotto, L.

AU - Zucchetta, P.

AU - Macri, C.

PY - 1995/3

Y1 - 1995/3

N2 - Adrenal scintigraphy using 131I-6-beta-iodomethyl-19-norcholesterol or 6-methyl-75Se-methyl-19-norcholesterol is a function-dependent imaging method which, in association with high-resolution spatial imaging techniques, plays an essential role in the study of adrenocortical hyperfunction. It can distinguish between bilateral cortical hyperplasia and monolateral adenoma or carcinoma and can lateralise the adenoma. In patients with Cushing syndrome, in addition to allowing a distinction to be made between ACTH-dependent forms and independent forms, adrenocortical scintigraphy is particularly appropriate to identify non-common forms of adenomatous hyperplasia. Adrenocortical scintigraphy, performed during dexamethasone administration, is an accurate mean of differentiating bilateral adrenal hyperplasia from monolateral forms (adenoma or carcinoma) in patients with Conn's syndrome. Owing to the gradual spread of high-resolution spatial imaging techniques, the problem of the diagnostic classification of so-called "incidentalomas" (clinically silent masses discovered by chance) is a subject of considerable interest. Adreno-cortical scintigraphy appears to be able to provide an important contribution to identifying the functional behaviour of these tumours. Since the early 80s meta-iodobenzyl-guanidine (MIBG), marked with 131I or 123I, with a structure similar to norepinephrine and characterized by selective tropism for sympathetic and chromaffin tissue, has been used for the scintigraphic study of adrenal medulla. MIBG scintigraphy has been found to be particularly appropriate for the study of intra- and extra-adrenal, single and multiple, benign and malignant pheochromocytomas. This method has a high overall sensitivity and specificity. Lastly, MIBG scintigraphy is useful in the study of neuroblastoma.

AB - Adrenal scintigraphy using 131I-6-beta-iodomethyl-19-norcholesterol or 6-methyl-75Se-methyl-19-norcholesterol is a function-dependent imaging method which, in association with high-resolution spatial imaging techniques, plays an essential role in the study of adrenocortical hyperfunction. It can distinguish between bilateral cortical hyperplasia and monolateral adenoma or carcinoma and can lateralise the adenoma. In patients with Cushing syndrome, in addition to allowing a distinction to be made between ACTH-dependent forms and independent forms, adrenocortical scintigraphy is particularly appropriate to identify non-common forms of adenomatous hyperplasia. Adrenocortical scintigraphy, performed during dexamethasone administration, is an accurate mean of differentiating bilateral adrenal hyperplasia from monolateral forms (adenoma or carcinoma) in patients with Conn's syndrome. Owing to the gradual spread of high-resolution spatial imaging techniques, the problem of the diagnostic classification of so-called "incidentalomas" (clinically silent masses discovered by chance) is a subject of considerable interest. Adreno-cortical scintigraphy appears to be able to provide an important contribution to identifying the functional behaviour of these tumours. Since the early 80s meta-iodobenzyl-guanidine (MIBG), marked with 131I or 123I, with a structure similar to norepinephrine and characterized by selective tropism for sympathetic and chromaffin tissue, has been used for the scintigraphic study of adrenal medulla. MIBG scintigraphy has been found to be particularly appropriate for the study of intra- and extra-adrenal, single and multiple, benign and malignant pheochromocytomas. This method has a high overall sensitivity and specificity. Lastly, MIBG scintigraphy is useful in the study of neuroblastoma.

UR - http://www.scopus.com/inward/record.url?scp=0029265251&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029265251&partnerID=8YFLogxK

M3 - Articolo

C2 - 7651280

AN - SCOPUS:0029265251

VL - 20

SP - 27

EP - 38

JO - Minerva Endocrinologica

JF - Minerva Endocrinologica

SN - 0391-1977

IS - 1

ER -