Morfometria nucleare e recettori estrogenici (RE) nel carcinoma duttale infiltrante della mammella.

Translated title of the contribution: Nuclear morphometry and estrogen receptors in infiltrating ductal carcinoma of the breast

C. Giardina, G. Serio, G. Simone, A. Pennella, E. Vacca, R. Ricco, D. Scordari, V. Pesce Delfino

Research output: Contribution to journalArticlepeer-review

Abstract

In this study ten cases of breast infiltrating ductal carcinoma have been considered. In all of them the content of ER has been evaluated by using monoclonal antibodies. Five of them were ER positive and five were ER negative. For the morphometric study ten nuclei of each case have been considered. By using the S.A.M. (Shape Analytical Morphometry) work-station an analytical study of the nuclear shape was performed. The first step was the extraction of fundamental shape which describes the basic shape of original contour without its irregularities. It was obtained by using two parametric equations. The second step was the evaluation of shape asymmetry by S.A.E. (Shape Asymmetry Evaluator). Finally the contour irregularities were evaluated by Fourier analysis. Along with analytical parameters, dimensions (area, perimeter and maximum diameter) were considered too. All obtained data were submitted to univariate statistical analysis (Student's T test) to compare the two groups (ER positive and ER negative tumors). Area, perimeter and maximum diameter were significatively greater in ER negative cases while analytical parameters were not discriminant between the two groups.

Translated title of the contributionNuclear morphometry and estrogen receptors in infiltrating ductal carcinoma of the breast
Original languageItalian
Pages (from-to)135-141
Number of pages7
JournalBollettino della Societa Italiana di Biologia Sperimentale
Volume66
Issue number2
Publication statusPublished - Feb 1990

ASJC Scopus subject areas

  • Medicine(all)

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