Nuclear phospholipase C: A novel aspect of phosphoinositide signalling

Lucia Manzoli, Anna Maria Billi, Irene Faenza, Alessandro Matteucci, Alberto M. Martelli, Daniela Peruzzi, Mirella Falconi, Sue Goo Rhee, R. Stewart Gilmour, Lucio Cocco

Research output: Contribution to journalArticlepeer-review


The role of polyphosphoinositides in cellular signalling is well known and recently it has also been shown that the nucleus is a site for both synthesis and hydrolysis of the phosphorylated forms of phosphatidylinositol. It has been demonstrated that phospholipase C specific for inositol lipids (PLC) is one of the main steps of the inositol lipid cycle. The PLC β family, and especially type β1, has given rise to considerable interest since, due to their common COOH-terminus they show nuclear localisation in addition to that at the plasma membrane. It is well established that an autonomous intranuclear inositide cycle exists, and that this cycle is endowed with conventional lipid kinases, phosphatases and PLCs. Among this latter the β1 type undergoes stimulation or inhibition under different stimuli and this implicates the β1 isoform as a key enzyme for mitogen-activated cell growth as well as for differentiation. Indeed, both the overexpression and the down-regulation of PLC β1, by means of antisense mRNA, have demonstrated that PLC plays a role in the nuclear compartment.

Original languageEnglish
Pages (from-to)3753-3756
Number of pages4
JournalAnticancer Research
Issue number5 A
Publication statusPublished - 1999


  • Nucleus
  • Phospholipase C
  • Signalling

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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