Nuclear physics meets medicine and biology: Boron neutron capture therapy

F. Ballarini, J. G. Bakeine, S. Bortolussi, P. Bruschi, A. M. Clerici, A. De Bari, P. Dionigi, C. Ferrari, M. A. Gadan, N. Protti, S. Stella, C. Zonta, A. Zonta, S. Altieri

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

BNCT is a tumour treatment based on thermal-neutron irradiation of tissues enriched with 10B, which according to the 10B(n,α) 7Li reaction produces particles with high Linear Energy Transfer and short range. Since this treatment can deliver a therapeutic tumour dose sparing normal tissues, BNCT represents an alternative for diffuse tumours and metastases, which show poor response to surgery and photontherapy. In 2001 and 2003, in Pavia BNCT was applied to an isolated liver, which was infused with boron, explanted, irradiated and re-implanted. A new project was then initiated for lung tumours, developing a protocol for Boron concentration measurements and performing organ-dose Monte Carlo calculations; in parallel, radiobiology studies are ongoing to characterize the BNCT effects down to cellular level. After a brief introduction, herein we will present the main activities ongoing in Pavia including the radiobiological ones, which are under investigation not only experimentally but also theoretically, basing on a Monte Carlo code recently extended to simulate cell killing.

Original languageEnglish
Title of host publicationCERN-Proceedings
PublisherCERN
Pages561-571
Number of pages11
Volume2
ISBN (Print)9789290833413
Publication statusPublished - 2010
Event2009 12th International Conference on Nuclear Reaction Mechanisms, NRM 2009 - Varenna, Italy
Duration: Jun 15 2009Jun 19 2009

Other

Other2009 12th International Conference on Nuclear Reaction Mechanisms, NRM 2009
CountryItaly
CityVarenna
Period6/15/096/19/09

ASJC Scopus subject areas

  • Nuclear and High Energy Physics

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  • Cite this

    Ballarini, F., Bakeine, J. G., Bortolussi, S., Bruschi, P., Clerici, A. M., De Bari, A., Dionigi, P., Ferrari, C., Gadan, M. A., Protti, N., Stella, S., Zonta, C., Zonta, A., & Altieri, S. (2010). Nuclear physics meets medicine and biology: Boron neutron capture therapy. In CERN-Proceedings (Vol. 2, pp. 561-571). CERN.