Abstract
The intestinal epithelium is structured in crypt-villus units which are responsible for its continuous renewal. These units are organized in a dynamic scenario in which proliferating progenitor cells are generated from stem cells in the crypts and migrate along the villus axis until their extrusion as differentiated cells at the surface epithelium. The mechanisms controlling cell transition involve transcription factors that switch on and off compartment-specific genes. The Wnt cascade represents the dominant force controlling cell fate in the crypt-villus axis. Mutations in this cascade result in the development of colorectal cancer. Life-style modifications and dietary regimens are epidemiologically recognized contributing factors for intestinal tumorigenesis. Nuclear receptors are a family of transcription factors functioning as sensors of dietary and endogenous molecules, thus translating nutritional and hormonal stimuli into transcriptional modifications. This review presents the role of nuclear receptors in intestinal carcinogenesis and explores their influence in maintenance of intestinal epithelium architecture.
| Original language | English |
|---|---|
| Pages (from-to) | 1523-1543 |
| Number of pages | 21 |
| Journal | Cellular and Molecular Life Sciences |
| Volume | 65 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - May 2008 |
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Keywords
- Crypts
- Gene expression
- Intestine
- Nuclear receptors
- Stem cells
- Villus
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Cell Biology
Cite this
Nuclear receptors, intestinal architecture and colon cancer : An intriguing link. / D'Errico, I.; Moschetta, A.
In: Cellular and Molecular Life Sciences, Vol. 65, No. 10, 05.2008, p. 1523-1543.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Nuclear receptors, intestinal architecture and colon cancer
T2 - An intriguing link
AU - D'Errico, I.
AU - Moschetta, A.
PY - 2008/5
Y1 - 2008/5
N2 - The intestinal epithelium is structured in crypt-villus units which are responsible for its continuous renewal. These units are organized in a dynamic scenario in which proliferating progenitor cells are generated from stem cells in the crypts and migrate along the villus axis until their extrusion as differentiated cells at the surface epithelium. The mechanisms controlling cell transition involve transcription factors that switch on and off compartment-specific genes. The Wnt cascade represents the dominant force controlling cell fate in the crypt-villus axis. Mutations in this cascade result in the development of colorectal cancer. Life-style modifications and dietary regimens are epidemiologically recognized contributing factors for intestinal tumorigenesis. Nuclear receptors are a family of transcription factors functioning as sensors of dietary and endogenous molecules, thus translating nutritional and hormonal stimuli into transcriptional modifications. This review presents the role of nuclear receptors in intestinal carcinogenesis and explores their influence in maintenance of intestinal epithelium architecture.
AB - The intestinal epithelium is structured in crypt-villus units which are responsible for its continuous renewal. These units are organized in a dynamic scenario in which proliferating progenitor cells are generated from stem cells in the crypts and migrate along the villus axis until their extrusion as differentiated cells at the surface epithelium. The mechanisms controlling cell transition involve transcription factors that switch on and off compartment-specific genes. The Wnt cascade represents the dominant force controlling cell fate in the crypt-villus axis. Mutations in this cascade result in the development of colorectal cancer. Life-style modifications and dietary regimens are epidemiologically recognized contributing factors for intestinal tumorigenesis. Nuclear receptors are a family of transcription factors functioning as sensors of dietary and endogenous molecules, thus translating nutritional and hormonal stimuli into transcriptional modifications. This review presents the role of nuclear receptors in intestinal carcinogenesis and explores their influence in maintenance of intestinal epithelium architecture.
KW - Crypts
KW - Gene expression
KW - Intestine
KW - Nuclear receptors
KW - Stem cells
KW - Villus
UR - http://www.scopus.com/inward/record.url?scp=44449138033&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=44449138033&partnerID=8YFLogxK
U2 - 10.1007/s00018-008-7552-1
DO - 10.1007/s00018-008-7552-1
M3 - Article
C2 - 18278436
AN - SCOPUS:44449138033
VL - 65
SP - 1523
EP - 1543
JO - Cellular and Molecular Life Sciences
JF - Cellular and Molecular Life Sciences
SN - 1420-682X
IS - 10
ER -