Nuclear reprogramming and adult stem cell potential

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Cell-based therapy may represent a new strategy to treat a vast array of clinical disorders including neurodegenerative diseases. Recent observations indicate that adult somatic stem cells have the capacity to contribute to the regeneration of different tissues, suggesting that differentiative restrictions are not completely irreversible and can be reprogrammed. Cell fusion might account for some changed phenotype of adult cells but it seems to be biologically irrelevant for its extreme rarity. Other experimental evidences are compatible with the hypothesis of wide multipotency of well-defined stem cell populations, but also with transdifferentiation and/or dedifferentiation. Further studies on nuclear reprogramming mechanisms are necessary to fulfil the promise for developing autologous cellular therapies.

Original languageEnglish
Pages (from-to)977-986
Number of pages10
JournalHistology and Histopathology
Volume20
Issue number3
Publication statusPublished - Jul 2005

Fingerprint

Adult Stem Cells
Cell Fusion
Cell- and Tissue-Based Therapy
Neurodegenerative Diseases
Regeneration
Stem Cells
Phenotype
Population
Therapeutics
Cellular Reprogramming

Keywords

  • Neurodegenerative disease
  • Stem cells
  • Therapy
  • Transdifferentiation

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology

Cite this

Nuclear reprogramming and adult stem cell potential. / Corti, S.; Locatelli, F.; Papadimitriou, D.; Strazzer, S.; Bonato, S.; Comi, Giacomo P.

In: Histology and Histopathology, Vol. 20, No. 3, 07.2005, p. 977-986.

Research output: Contribution to journalArticle

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