Abstract
In the ongoing process of uncovering molecular abnormalities in neurodegenerative diseases characterized by toxic protein aggregates, nucleo-cytoplasmic transport defects have an emerging role. Several pieces of evidence suggest a link between neuronal protein inclusions and nuclear pore complex (NPC) damage. These processes lead to oxidative stress, inefficient transcription, and aberrant DNA/RNA maintenance. The clinical and neuropathological spectrum of NPC defects is broad, ranging from physiological aging to a suite of neurodegenerative diseases. A better understanding of the shared pathways among these conditions may represent a significant step toward dissecting their underlying molecular mechanisms, opening the way to a real possibility of identifying common therapeutic targets.
Original language | English |
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Article number | 25 |
Journal | Translational Neurodegeneration |
Volume | 9 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jul 3 2020 |
Keywords
- Aging
- Neurodegeneration
- Neurodegenerative disease
- Nuclear pore complex
- Nucleo-cytoplasmic transport
- Protein aggregate
ASJC Scopus subject areas
- Clinical Neurology
- Cognitive Neuroscience
- Cellular and Molecular Neuroscience