Nucleo-cytoplasmic transport defects and protein aggregates in neurodegeneration

Giacomo Bitetto, Alessio Di Fonzo

Research output: Contribution to journalReview articlepeer-review


In the ongoing process of uncovering molecular abnormalities in neurodegenerative diseases characterized by toxic protein aggregates, nucleo-cytoplasmic transport defects have an emerging role. Several pieces of evidence suggest a link between neuronal protein inclusions and nuclear pore complex (NPC) damage. These processes lead to oxidative stress, inefficient transcription, and aberrant DNA/RNA maintenance. The clinical and neuropathological spectrum of NPC defects is broad, ranging from physiological aging to a suite of neurodegenerative diseases. A better understanding of the shared pathways among these conditions may represent a significant step toward dissecting their underlying molecular mechanisms, opening the way to a real possibility of identifying common therapeutic targets.

Original languageEnglish
Article number25
JournalTranslational Neurodegeneration
Issue number1
Publication statusPublished - Jul 3 2020


  • Aging
  • Neurodegeneration
  • Neurodegenerative disease
  • Nuclear pore complex
  • Nucleo-cytoplasmic transport
  • Protein aggregate

ASJC Scopus subject areas

  • Clinical Neurology
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience


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